Paper Information

Title: 

VANADIUM AND DIABETES: CAN IT REPLACE INSULIN IN DIABETIC MELITUS PATIENTS

Type: PAPER
Author(s): DEHGHANI GH.A.*
 
 *DEPARTMENT OF PHYSIOLOGY, ENDOCRINE AND METABOLISM RESEARCH CENTER, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

About one hundred years ago, a vanadium-containing compound was assessed clinically for use in treatment of human diabetic patients. At that time the results were somewhat ambiguous and intriguing. In 1980s the first Phase of animal experiments indicated that Vanadium compounds (vanadium) mimic or enhance most of the metabolic actions of insulin in experimental induced diabetic rats. In 1992 we found that besides having insulin-like activity vanadium has trophic actions on pancreatic beta cells of experimental models of type 1 diabetes. In severe diabetic rats, long term vanadium consumption not only through its insulin-like activity ameliorates hyperglycemia, it alleviate diabetes by proliferating viable beta cells to restore insulin secretion. Recent TEM (transmission electron microscopy) studies of the ultra structure of beta cells of diabetic rats proved that vanadium is capable of provoking the proliferation or regeneration of beta cells by repairing and spreading out their intracellular organelles with the possibility of synthesizing and storing more insulin.  These compounds are also gained attention as candidates for oral therapy in both types of diabetes. Therefore, in a clinical trial we chose 14 type I diabetic patients (insulin dependent diabetic patients; IDDM) received oral vanadium (3 capsules of 50-100 mg of VOSO4, daily) for a period of 24 months. Long term vanadyl consumption in man did not show hepatic, renal and cardiovascular disorders nor did it have any hematological side effects. The only problem we saw at the first 2-4 weeks of vanadyl therapy was that some patients started with diarrhea and epigastric pain in which disappeared with continued treatment. In these patients the daily dose of insulin decreased by 30%. They were able to have a better control on their fasting blood glucose level (36% reduction in FBS) and their blood cholesterol decreased by 22% without a significant change in TG. Therefore, we think: 1) someday vanadium will be a drug of choice in helping diabetic patients to have a better control of their blood glucose may gradually replace insulin. 2) More importantly if it works on pancreatic beta cells of type I diabetic patients, as is the case in acute and chronic type I diabetic rats, and these cells remain alive, active and regularly synthesis insulin as of normal cells they may alleviate diabetes mellitus permanently.

 
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