Paper Information

Title: 

PHARMACOLOGICAL BASIS FOR THE MEDICINAL USE OF TURMERIC IN ALZHEIMER'S DISEASE

Type: POSTER
Author(s): AHMED T.,JABAR A.*,GILANI A.H.
 
 *NATURAL PRODUCT RESEARCH DIVISION, DEPARTMENT OF BIOLOGICAL AND BIOMEDICAL SCIENCES, AGA KHAN UNIVERSITY MEDICAL COLLEGE, KARACHI, PAKISTAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Curcuminoids (a mixture of curcumin, bisdemethoxycurcumin and demethoxycurcumin) which are considered to represent turmeric were studied in an attempt to rationalize the medicinal use of Turmeric in Alzheimer's disease (AD).
Methods: Acetylcholinesterase (AChE) inhibitory activity was measured in the in-vitro and ex-vivo rat brain homogenates. Neuroprotective effect of curcuminoids was measured in rat primary cortical neurons. Calcium channel blocking (CCB) activity was carried out in isolated rabbit jejunum.
Results: Curcuminoids exhibited a dose-dependent inhibition of the in-vitro AChE with IC50 (µM) value of 20, curcumin 68, demethoxycurcumin 33 and bisdemethoxycurcumin 17. In the ex-vivo AChE assay, curcuminoids (10 mg/kg) significantly inhibited (P<0.01) AChE in rat frontal cortex (58%) and hippocampus (66%). In rat primary cortical cells curcuminoids and all three components at 20 µM showed significant neuroprotection in glutamate induced neurotoxicity. In jejunal preparations, curcuminoids caused inhibition of spontaneous and K+-induced contractions with respective IC50 values of 31 and 13, a pattern of activity similar to that of verapamil. Bisdemethoxycurcumin and demethoxycurcumin up to the dose of 100 µM did not show any CCB activity.
Conclusions: These data indicate that curcuminoids possess unique combination of activities (AChE inhibitory, neuroprotective and CCB), which may explain the usefulness of turmeric in AD, though additional mechanisms cannot be ruled out. Further studies on the individual components of curcuminoids are in progress.

 
Keyword(s): 
 
Yearly Visit 17   tarjomyar
 
Latest on Blog
Enter SID Blog