Paper Information

Title: 

ANTIMICROBIAL EFFECTIVITY OF CINNAMUM ZEYLANICUM AGAINST HELICOBACTER PYLORI

Type: POSTER
Author(s): GHOLOUBI I.,KHAJEH KARAM ALDINI M.,BAKHTIARI RAMEZANI M.,FAZLI BAZAZ SEDIGHEH,KHAMEHCHIAN ELHAM
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

In this study, the effect of extract of Cinamomu zeylanicum on growth inhibition of Helicobacter pylori has been evaluated. The dried and powdered plant was extracted with methanol using suxhlet apparatus. Different concentrations of extract (50, 100, 150, 200, 225, 250 mg/ml) in methanol were prepared and tested against clinical isolates of H. pylori using agar- plate method. Amoxicillin (25 µg/disc), tetracycline (30 µg/disc), metronidazol (5, 20 µg/disc) were used as positive controls. The H. pylori isolates were incubated at 37°C for 5-7 days under microaerophilic atmosphere. The zone of inhibition was measured after one week of incubation. The zone of inhibition 330, 660, 990, 1320, 1480, 1650 µg of dry extract per hole on 35 clinical isolates were 19.2, 22.16, 25.2, 29.01, 31.10, 32.86 mm, respectively indicating a significant antibacterial activity. The MIC determined by agar dilution method was 1.3 mg/ml for all isolates. The results indicated that Cinamon extract had inhibitory effects on H. pylori in vitro.

 
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