Paper Information

Title: 

COMPARISION THE OF EFFECT OF NIGELLA SATIVA SUPP AND CLOTRIMAZOLE VAGINAL TABLET IN TREATMENT OF VAGINAL CANDIDIASIS

Type: POSTER
Author(s): SAGHAFI N.,RAKHSHANDEH H.,SAJADI A.,SOVIZI M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Vulvovaginal candidiasis (VVC) is one of the most common genital infections, which has many different therapeutic methods. Some herbal research suggest Nigella sativa that has antifungal activity against Candida. The aim of this study was to compare the effect of Nigella sativa suppository and clotrimazole vaginal tablet in the treatment of the women with VVC.
Methods: Randomized, prospective, case control studies were done on 100 nonpregnat women with symptomatic vaginal candidiasis. Nigella sativa supp, Were provided by pharmacologist and then the patients whose mycologic culture was positive where randomly allocated in 2 group of vaginal Nigella sativa supp (2%) and vaginal clotrimazole tablet. All patients were treated daily for 7 days and assessed for clinical and mycological results, 1-2 weeks after the end of treatment .Data were obtained by interview and observation methods and were analyzed by SpSS Software using chi square, T student test and paired samples t-test by confidence of 95%.
Results: successful response according clinical results were reported in 88% in Nigella sativa users and 66% clotrimazole users (P=0.024). There was significant difference between clinical results after treatment in two groups. Also this study shows significant difference between mycological results in both groups (respectively 84% aginst 62%) (P=0.013).
Conclusion: According to the results, percentage of successful response in users of Nigella sativa supp. was more than clotrimazole vagnial tablet and there was significant difference between these groups according to clinical result, we suggest for using of Nigella sativa supp, as Alternative herbal treatment of vaginal candidiasis.

 
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