Paper Information

Title: 

EFFECT OF FLUVOXAMINE ON CONCENTRATION OF TESTOSTERONE AND SPERMATOGENESIS IN RAT

Type: POSTER
Author(s): TAVAKOLI F.,MOKHTARI M.,SHARIATI M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Fluvoxamine is a selective serotonin reuptake inhibitor. That important in the treatment of obsessive - compulsive disorder, bulimia, panic and depression.
Methods: The animals used in this study were 50 wistar male mature rats, that divided in 5 group. They included control, sham and experimental groups. The control group had no drug. The sham group received 0.05 ml of ethanol dissolved in 0.15 ml of destilated water. The experimental group received 15, 30, 60 (mg/kg) drug daily for fourteen days intraperitoneally. After fourteenth day, sample blood was taken from the animal’s ̉hearts. To measure the serum concentration of LH, FSH and testosterone hormones, the testis were taken out and sliced for tissue coloring.
Result: The results were evaluated through ANOVA, tukey, Duncan and t-test. The result showed that serum concentration of LH and FSH and spermatogenesis chain in experimental groups did not show significant difference in compared with control group, but fluvoxamine at high dose decreased serum concentration of testosterone.
Discussion: Approximately, fluvoxamine caused the reduction of the testes function for the testosterone secretion through the reduction of sensitivity of LH receptors in the leydig cells. In addition, through the increase of prolactin, melatonin and serotonin secretion, fluvoxamine probably caused the inhibition of enzymes in the synthesizing of steroides, which led to the decrease of testosterone synthesization. The results of the study on the tissue of testicles showed that after fourteen days, fluvoxamine didn’t have any significant effect on the chain of spermatogenesis and compaction of sertoli and leydig cells.

 
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