Paper Information

Title: 

A SURVEY OF NORFLOXACIN HISTOPATHOLOGICAL EFFECT ON DEVELOPMENT OF RAT FETUS HEART

Type: POSTER
Author(s): PEYROVI T.*,KHAKI ARASH,ZAHEDI AFSHIN,MIKANIKI E.
 
 *DEPARTMENT OF HISTOLOGY, FACULTY OF MEDICINE, URMIA UNIVERSITY OF MEDICAL SCIENCES, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Norfloxacin is an antibiotic from fluoroquinolone with a wide range and widely used in various infectious diseases. Nearly 600 teratogenic factors have been known that cause congenital disease in laboratory animal. One of these factors is drugs. The aim of this study was affect of Norfloxacin on development of rat fetus heart.
Method: In this study 4- month- age vistar rats with 200 gram weight are used that were housed in environmentally controlled room. A group of 3 female were caged with a single male of proven fertility overnight. Finding of vaginal plug on the following morning was regarded as a gestational day 0.  Pregnant rats are divided into 2 groups (control and experiment). The first ones are fed by rodent special food and the second ones are fed by rodent special food plus 70 mg/kg norfloxacin every day. After delivery tissue specimen from rat newborns heart dissected apart and prepared for light microscopy.
Results: The result showed that in the group receiving norfloxacin in compare with control group, myocardial cells were smaller and contains highly densed nuclei.
Conclusion: To sum up the results show that the above mentioned drug could be transferred through plasenta and affect on normal development of myocardial cells. This change could have negative on function of above organ after birth.

 
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