Paper Information

Title: 

EVALUATION OF EFFICACY OF ORAL NALTREXONE IN THE TREATMENT OF UREMIC PRURITUS AND ITS COMPARISON WITH HYDROXYZIN

Type: POSTER
Author(s): PEZESHKPOUR F.A.Z.,FAMILI SOROUR ALZAMAN,KIAFAR B.,MOJAHED MOHAMMAD JAVAD
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Uremic pruritus is a common problem in advanced renal insufficiency patients. Naltrexone, an opioid antagonist, seems to be promising. The object of this trial is to evaluate efficacy of oral naltrexone in the treatment of uremic pruritus and its comparison with hydroxyzine.
Methods: 20 patients undergoing dialysis attending dialysis center of Mashhad's Qaem and Emam Reza hospital entered the trial. Patients received 50mg/day Naltrexone for 2 weeks. At the beginning an at the and of each week. Their pruritus was assessed using a questionnaire. Then treatment stopped for a week and a second course with 35mg Hydroxyzine daily started and the same assessments performed. A more than 50 percent decrease itching scale accepted as a positive response.
Results: 14 patients completed the trial. Form theses patients 10 had a positive response to naltrexone and 4 patients didn't. 6 patients found Hydroxyzine to be effective and 4 non-effective. In 4 patients not responding to naltrexone, Hydroxyzine was ineffective too. In statistical analysis between the two groups P<0.05 resulted. In this trial naltrexone was superior to Hydroxyzine in controlling itching of uremic patients.

 
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