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Journal:   THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)   Fall 2020 , Volume 17 , Number 3 ; Page(s) 242 To 257.
 
Paper: 

Platelet Refractoriness And How It Is Formed

 
 
Author(s):  Milani S.*, Yari F.
 
* Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
 
Abstract: 
Background and Objectives: Transfusion of platelet has become one of the main treatments for thrombocytopenic patients to reduce the severity and frequency of bleeding consequences. Failure to attain the desired level of platelets in a patient following platelet transfusion is defined as platelet refractoriness. The purpose of present paper is to review and study the mechanisms involved in the formation of platelet refractory. Materials and Methods: This article reviews the effective factors present in platelet recipients and donors, and considers the characteristics of platelet products that may have impacts on platelet refractoriness. The search is conducted through scientific databases including Science Direct, PubMed, Medline, SI, Scopus, and Ma iran by the keywords “ Platelet Refractory” , “ Alloantibody” , “ HLA” , “ Platelet Transfusion” and their Persian equivalents. Finally out of about 130 related articles, 97 articles were used for the review. Results: Generally, platelet refractoriness occurs in two ways including immunologic and nonimmunologic. The immunologic way is due to alloimmunization against alloantigens as a result of contact with human leukocyte antigens (HLA), Human Platelet Antigens (HPA). Non immunologic conditions such as fever, spleen enlargement and use of certain medications are responsible to 80% of platelet refractory incidence. Conclusions: Identification of different features and mechanisms in platelet refractoriness including immunologic and non-immunologic factors have an important role in control, prevention and management of the disease.
 
Keyword(s): Platelets,Transfusion,Thrombocytopenia
 
 
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APA: Copy

MILANI, S., & YARI, F. (2020). Platelet Refractoriness and how it is formed. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 17(3 ), 242-257. https://www.sid.ir/en/journal/ViewPaper.aspx?id=786732



Vancouver: Copy

MILANI S., YARI F.. Platelet Refractoriness and how it is formed. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON). 2020 [cited 2022August13];17(3 ):242-257. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=786732



IEEE: Copy

MILANI, S., YARI, F., 2020. Platelet Refractoriness and how it is formed. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), [online] 17(3 ), pp.242-257. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=786732.



 
 
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