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Paper Information

Journal:   JOURNAL OF CHEMICAL HEALTH RISKS (JCHR)   2018 , Volume 8 , Number 4; Page(s) 323 To 328.
 
Paper: 

Synthesis and Cytotoxic Evaluation of 2-Pyrazoline Derivative on Leukemia Cancer Cell Line K562

 
 
Author(s):  SHAABANZADEH MASOUD*, BIKHOF TORBATI MARYAM
 
* Department of Chemistry, Damghan Azad University, Damghan, Iran
 
Abstract: 
The 2-pyrazoline derivatives have a wide range of biological effects, such as anti-viral, anti-bacterial, anti-fungal, anti-depressant and anti-cancer effects. Studies have shown that compounds containing 2-pyrazoline along with another heterocycles may show more effective biological properties. In this study, a 2-pyrazoline derivative with a spiro-indenoquinoxaline ring at C3 position was synthesized by one-pot microwave-assisted method and its chemical structure was confirmed by 1H NMR spectroscopy. The cytotoxic effects of the compound were evaluated on the K562 cell line and phytohemagglutinin-activated peripheral blood mononuclear cells (PHA+PBMC) by MTT assay. Additionally, the cytotoxic effects of cisplatin on these cells were investigated and compared with those of 2-pyrazoline. The IC50 values obtained from the 2-pyrazoline derivative effects on the K562 cell line and PHA+PBMC cells were 45 and 55 μ g/mL respectively, while cisplatin inhibited proliferation of the same cells with IC50 value 1. 71 and 7. 8 μ g/mL respectively. The results of this study showed that the synthesized derivative had a cytotoxic activity on the K562 cancer cell line at higher concentrations than cisplatin.
 
Keyword(s): 2-Pyrazoline,Indenoquinoxaline,Anticancer,Cytotoxic effect,Leukemia,K562 cell line,PBMC
 
 
References: 
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Citations: 
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APA: Copy

SHAABANZADEH, M., & BIKHOF TORBATI, M. (2018). Synthesis and Cytotoxic Evaluation of 2-Pyrazoline Derivative on Leukemia Cancer Cell Line K562. JOURNAL OF CHEMICAL HEALTH RISKS (JCHR), 8(4), 323-328. https://www.sid.ir/en/journal/ViewPaper.aspx?id=668730



Vancouver: Copy

SHAABANZADEH MASOUD, BIKHOF TORBATI MARYAM. Synthesis and Cytotoxic Evaluation of 2-Pyrazoline Derivative on Leukemia Cancer Cell Line K562. JOURNAL OF CHEMICAL HEALTH RISKS (JCHR). 2018 [cited 2021August01];8(4):323-328. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=668730



IEEE: Copy

SHAABANZADEH, M., BIKHOF TORBATI, M., 2018. Synthesis and Cytotoxic Evaluation of 2-Pyrazoline Derivative on Leukemia Cancer Cell Line K562. JOURNAL OF CHEMICAL HEALTH RISKS (JCHR), [online] 8(4), pp.323-328. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=668730.



 
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