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Paper Information

Journal:   JOURNAL OF CHEMICAL HEALTH RISKS (JCHR)   2018 , Volume 8 , Number 4; Page(s) 305 To 312.

Nano-TiO2 an Efficient, Clean and Eco-friendly Catalyst for Synthesis of Naphthoxazinone Derivatives as High Potent Antibacterial Agents

Author(s):  Pourshamsian Khalil*
* Department of Chemistry, Tonekabon Azad University, Tonekabon, Iran
Oxazines naturally occurs and synthetically exhibit wide-ranging biological activity. In this study, a highly practical and efficient of 1, 2-dihydro-1-phenylnaphtho[1, 2-e][1, 3]oxazine-3-one derivatives was developed via a multi-component reaction of 2-naphthol, aldehydes and urea in the presence of nano-titanium oxide as solid, recyclable catalyst at one-pot and solvent-free conditions. These synthetic compounds 2a-e were evaluated as potential antibacterial agents. The structures of products were confirmed by spectral analysis FT-IR and 1H NMR. The antibacterial activity of the compounds was screened against Staphylococcus aureus and Escherichia coli. These results showed that these compounds exhibited significant to moderate activities against both Gram (+) and Gram (-) organisms.
Keyword(s): Antibacterial agents,Naphthooxazinones,Nano-TiO2,Eco-friendly catalyst
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