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Paper Information

Journal:   INTERNATIONAL JOURNAL OF NANO DIMENSION (IJND)   Spring 2019 , Volume 10 , Number 2; Page(s) 169 To 179.
 
Paper: 

Electrospun biocompatible Gelatin-Chitosan/Polycaprolactone/ Hydroxyapatite nanocomposite scaffold for bone tissue engineering

 
 
Author(s):  Arab Ahmadi Samira, PEZESHKI MODARESS MOHAMAD, IRANI SHIVA*, ZANDI MOJGAN
 
* Department of Biology, Science and Research Azad University, Tehran, Iran
 
Abstract: 
In recent years, nanocomposite scaffolds made of bioactive polymers have found multiple applications in bone tissue engineering. In this study composite nanofibrous structure of gelatin (Gel)/chitosan (Cs)-polycaprolactone (PCL) containing hydroxyapatite (HA) were fabricated using co-electrospinning process. To assay the biocompatibility and bioactivity of electrospun nanocomposite scaffolds, the behavior of human osteosarcoma cells (MG63) on fabricated nanofibers was evaluated using scanning electron microscopy (SEM), fluorescence microscopy analysis, measuring calcium deposits and MTT assay. The SEM micrographs at days 3 and 7 showed high cell attachment and spreading on the nanofibrous scaffolds. The MTT results demonstrated the proliferation of MG-63 cells during 10 days and the positive effect of nanofibers in comparison of cell culture plate. Considering the proliferation rate and calcification extent, the Gel-Cs-HA nanofibers reveal highest biocompatibility for osteoblast cells which could be attributed to the smaller diameter fibers and more mechanical strength in the Gel-Cs-HA scaffold.
 
Keyword(s): Bone Tissue Engineering,Chitosan,Gelatin,Hydroxyapatite,Osteoblast,Polycaprolactone
 
 
References: 
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Citations: 
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APA: Copy

Arab Ahmadi, S., & PEZESHKI MODARESS, M., & IRANI, S., & ZANDI, M. (2019). Electrospun biocompatible Gelatin-Chitosan/Polycaprolactone/ Hydroxyapatite nanocomposite scaffold for bone tissue engineering. INTERNATIONAL JOURNAL OF NANO DIMENSION (IJND), 10(2), 169-179. https://www.sid.ir/en/journal/ViewPaper.aspx?id=668717



Vancouver: Copy

Arab Ahmadi Samira, PEZESHKI MODARESS MOHAMAD, IRANI SHIVA, ZANDI MOJGAN. Electrospun biocompatible Gelatin-Chitosan/Polycaprolactone/ Hydroxyapatite nanocomposite scaffold for bone tissue engineering. INTERNATIONAL JOURNAL OF NANO DIMENSION (IJND). 2019 [cited 2021August04];10(2):169-179. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=668717



IEEE: Copy

Arab Ahmadi, S., PEZESHKI MODARESS, M., IRANI, S., ZANDI, M., 2019. Electrospun biocompatible Gelatin-Chitosan/Polycaprolactone/ Hydroxyapatite nanocomposite scaffold for bone tissue engineering. INTERNATIONAL JOURNAL OF NANO DIMENSION (IJND), [online] 10(2), pp.169-179. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=668717.



 
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