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Paper Information

Journal:   INTERNATIONAL JOURNAL OF MOLECULAR AND CLINICAL MICROBIOLOGY   2018 , Volume 8 , Number 1; Page(s) 922 To 930.
 
Paper: 

Bactericidal activity of pigments isolated from Fars province (Iran) environmental bacteria on MDR clinical isolates of Acinetobacter

 
 
Author(s):  MOAZAMIAN ELHAM, EMAMI AMIR*, Mehdizadeh Hengameh, PIRBONYEH NEDA
 
* Burn and Wound Healing Research Center, Microbiology Department, Shiraz University of Medical Sciences, Shiraz, Iran
 
Abstract: 
Antimicrobial agents are important compounds in reducing infections, but the spread of resistant pathogens diminished the effectiveness of these compounds. This study aimed to isolate the local bacterial pigments with specific antibacterial activity against clinical Acinetobacter baumannii isolates in burn centers. For this, pigmented bacteria isolated from environments in Fars province (Iran) and adjoining areas during Jun-July of 2017. Colonies with various pigment colors were isolated in pure cultures on nutrient agar. After identification of the pigmented bacteria, the extracted pigments were evaluated for antibacterial activity against previous confirmed clinical isolates of Acinetobacter baumannii with multi-drug resistant specification. Red pigment extract from Serratia marcescens (Prodigiosin) has the most proper inhibitory effect on the studied Acinetobacter baumannii isolates. The related bacterium was isolated from a salty region entitled Maharlo Lake. The minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) value of the pigment extracted from selected bacterium ranged from 2500-5000 μ g/ml and 1250-2500μ g/ml, respectively. The extracted pigments had a different antimicrobial activity against the studied clinical isolates, but on the basis of MBC/MIC results, the extracted prodigiosin pigment was the most effective anti-Acinetobacter agent. However, further studies are needed to use this pigment as a new antimicrobial agent or disinfectant on burn wounds.
 
Keyword(s): Organic pigments,Acinetobacter,Wound infection,multi drug resistant
 
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