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Paper Information

Journal:   JOURNAL OF ANIMAL BIOLOGY   winter 2018 , Volume 10 , Number 2 #p00550; Page(s) 71 To 79.

Effect of Hydroalcoholic Extract of Trachyspermum copticum on Anxiety in Male Rats

Author(s):  Mohammadi Manesh Z., HEIDARIEH NASRIN
Anxiety is a common disorder of unknown origin is associated with an unpleasant feeling. According to the anxiolytic effects TC traditional medicine, Trachyspermum copticum effect on anxiety male Wistar rats was investigated. T. copticum seed after detection by the university herbarium, hydro-alcoholic extract was extracted by Soxhlet and the extract powder was prepared using smart legitimate. Male Wistar rats (230 ± 20 gr) were placed. In groups intact, recipient of the DMSO (solvent extraction) (0. 3 ml), received extract in different doses of 50, 25, 15 mg/kg. All injections were performed intraperitoneally. Half an hour after injection, anxiety was measured using the elevated plus maze. Indicators of anxiety for 5 min, including time spent and number of entries into the open arm was recorded. Data were analyzed by ANOVA statistical tests and Tukey test. The group receiving the extract solvent (DMSO) compared to intact in time spent and number of entries into the open arm did not show a significant difference. The group receiving a dose of 15 mg/kg compared to the group receiving DMSO in time spent and number of entries into the open arm showed a significant increase. T. copticum hydroalcoholic extract has anxiolytic effects in low doses.
Keyword(s): hydroalcoholic extract,Trachyspermum copticum,Anxiety,elevated plus maze,Male rats
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