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Paper Information

Journal:   JOURNAL OF ANIMAL BIOLOGY   winter 2018 , Volume 10 , Number 2 ; Page(s) 61 To 70.

Effect of Subacute Toxicity Nano Zinc Oxide (ZnO NPs) on Oxidative Stress Enzymes of Roach (Rutilus rutilus caspicus)

Today, the excessive use of zinc oxide nanoparticles (ZnO NPs) has led to concerns about the potential environmental hazards caused by the presence of these particles in aquatic ecosystems. Therefore, the aim of this study was to investigate the toxic effects of zinc oxide nanoparticles (0. 02, 0. 05 and 0. 1 mg/L) on the oxidative stress enzymes in brain tissue of roach during a period of 7 days. After homogenization of the brain tissue, the activity of oxidative stress enzymes such as superoxide dismutase (SOD), glutathione-S transferase (GST), catalase (CAT), glutathione (GSH) and malondialdehyde (MDA) was determined using biochemical methods. The SOD, CAT and GST activities were significantly increased by exposure to 0. 1 mg/ml zinc nanoparticles compared with other concentrations in brain tissue of roach (P<0. 05). However, the amount of glutathione decreased with increasing exposure dose. In amount of malondialdehyde dose-dependent manner was observed, since the maximum concentration was recorded at 0. 1 mg/ml of nanoparticles (4. 5 ± 5. 3 nmol/g wet). The subacute toxicity of nanoparticles leads to the induction of free radical and oxidative stress in brain tissue of roach. The increase in the activity of antioxidant enzymes causes antioxidant defense system activation for scavenger in free radicals.
Keyword(s): Rutilus rutilus caspicus,Oxidative stress,zinc oxide nanoparticles,Brain tissue
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