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Paper Information

Journal:   MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)   2018 , Volume 32 , Number 1; Page(s) 0 To 0.
 
Paper: 

Changes in the size of the thyroid in patients with benign non-toxic multinodular goiter after radioactive iodine therapy

 
DOI: 

10.14196/mjiri.32.131

 
Author(s):  HEYDARI IRAJ, HONARDOOST MARYAM, MORADI SEDIGHEH, GOLGIRI FATEMEH, Dehnad Hamidreza, Moradi Saba, ZIAEE AMIR*
 
* Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism ,Iran University of Medical Sciences Tehran, Iran
 
Abstract: 
Background: Multinodular goiter (MNG) is regarded as one of the most common causes of hyperthyroidism, particularly in areas of mild-to-moderate iodine deficiency. The present study aims to explore the effects of the radioactive iodine (RAI) therapy on benign non-toxic MNG and evaluate its side effects. Methods: Patients with benign non-toxic MNG entered the study. Ultrasonography was applied to calculate the percentage of the decrease in the size of the thyroid before and six months minimum after the treatment. Chi-square, Mann-Whiteny-U and T-test were done using SPSS v. 18. 0 (p<0. 05). Results: The volumes of the thyroid lobes and nodules decreased significantly due to RAI therapy (p<0. 001). The total volume of the thyroid, volume of the right nodule, and volume of the left nodule decreased by 77. 8%, 40. 7%, and 34. 6% respectively. Conclusion: According to the results of the current study, RAI therapy is an effective treatment method although it has short-term side effects. This treatment option is recommended for patients with benign non-toxic MNG, notably those who cannot be a candidate for surgery. This treatment affects the size of the thyroid and its nodules significantly and decreases almost all of the complications.
 
Keyword(s): Multinodular goiter,Nodule,Radioactive iodine therapy,Thyroid
 
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