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Paper Information

Journal:   JOURNAL OF ANIMAL BIOLOGY   fall 2018 , Volume 11 , Number 1 ; Page(s) 17 To 26.

Protecting Effect Extracts of Satureja bachtiarica and Thymus daenensis Celak against Hepatic Fibrosis Induced by Thioacetamide on Rat

Author(s):  SAZEGAR H., FADAEI F., Mashadizadeh sh., ZIA JAHROMI N., Sadeghi Samani f.
nowadays, one of the problems of human societies is liver diseases and using chemical drugs with their side effects, causing the researchers change their approaches towards new sources of herbal drugs. The aim of this study was to investigate the effect of Satureja bachtiarica and Thymus daenesis Celak the liver damage is caused by injection thioacetamide. 54 male wistar rats were randomly selected and divided into 9 groups of 6 each groups the (first sahed, second of positive control, third of negative control, fourth, fifth, sixth extracts of Satureja bachtiarica with 5, 10 and 20 miligram per kilogram, seven, eight and nine extract of Thymus daenensis Celak with 5, 10 and 20 mg/kg extract were given by gavage. Thioacetamide first for three week and twice weekly a rats of 1cc to all groups except the control group were injection then gavage for 14 days savory and thyme extract groups were treated with the extract and the positive drug control group treated with 8 mg/kg capsule sibilinin slap for 14 days. then the blood samples were taken and liver of rats. Histopathologic study suggests that liver lesions compared to the control group is related to the negative control group. Aspartate aminotransferase and alanine aminotransferase well as in the study were assessed and showed that extracts of thyme daenensis has a positive effect on liver fibrosis. By studying the findings, it seems that Flavonoid compounds and phenolic in Thymus daenesis Celak and Satureja bachtiarica can decrease the toxic effects induced By thioacetamide In liver tissue of Mice.
Keyword(s): Thioacetamide,Satureja bachtiarica,Thymus daenesis Celak,liver enzymes
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