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Paper Information

Journal:   JOURNAL OF ANIMAL BIOLOGY   spring 2018 , Volume 10 , Number 3 ; Page(s) 65 To 74.
 
Paper: 

The Effect of Cinnamon Extract (Cinnamum zeylanicum) on Catalepsy in Male Mice Model of Parkinson's Disease

 
 
Author(s):  Mohammad Ali Mansouri m.*, MOAZEDI A.A., PARHAM GH.A.
 
* Department of Biology, Shahid Chamran University of Ahvaz, Ahvaz, Iran
 
Abstract: 
Catalepsy or muscle rigidity is a neurological disease characterized by muscle stiffness or rigidity of muscles, organs decreased sensitivity to pain and stability regardless of external stimuli-known and one of the main symptoms of Parkinson's disease is considered. Due to the increasing levels of acetylcholine in the brain, treatment is focused on the use of muscarinic receptor antagonists. Despite relieve the symptoms, there are severe side effects. In this study, the effect of cinnamon extract on catalepsy in mice model of Parkinson's disease was conducted. Overall, 70 male mice (30 ± 2 g) were randomly divided into seven groups: control group, rotenone solvent, rotenone group and 4 groups of rotenone, subsequent doses 100, 200, 400 and 600 mg/kg cinnamon extract. To create models of Parkinson's disease, rotenone (2 mg/kg/ 48 h) was administered for 19 d and creating models of Parkinson's disease was evaluated. After verification of the model, different doses of cinnamon for 20 d (every 48 h) were injected intraperitoneally (IP). The effects of cinnamon extract on catalepsy was compared with other groups and the results were analyzed by ANOVA and Tukey test. PP<0. 05). Cinnamon could reduce catalepsy in mice models of Parkinson's disease, probably due to antioxidant compounds and flavonoids and the impact of these compounds on the nervous system.
 
Keyword(s): catalepsy,Cinnamon extract,Rotenone,Mice,Parkinson's disease
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

Mohammad Ali Mansouri, m., & MOAZEDI, A., & PARHAM, G. (2018). The Effect of Cinnamon Extract (Cinnamum zeylanicum) on Catalepsy in Male Mice Model of Parkinson's Disease. JOURNAL OF ANIMAL BIOLOGY, 10(3 ), 65-74. https://www.sid.ir/en/journal/ViewPaper.aspx?id=668092



Vancouver: Copy

Mohammad Ali Mansouri m., MOAZEDI A.A., PARHAM GH.A.. The Effect of Cinnamon Extract (Cinnamum zeylanicum) on Catalepsy in Male Mice Model of Parkinson's Disease. JOURNAL OF ANIMAL BIOLOGY. 2018 [cited 2021July31];10(3 ):65-74. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=668092



IEEE: Copy

Mohammad Ali Mansouri, m., MOAZEDI, A., PARHAM, G., 2018. The Effect of Cinnamon Extract (Cinnamum zeylanicum) on Catalepsy in Male Mice Model of Parkinson's Disease. JOURNAL OF ANIMAL BIOLOGY, [online] 10(3 ), pp.65-74. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=668092.



 
 
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