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Paper Information

Journal:   JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)   fall 2018 , Volume 12 , Number 3 ; Page(s) 95 To 101.

Optimization of catalyst for cross-coupling reaction of pyridine n-oxides and benzofurans for the synthesis of biologically active compounds

Author(s):  Kianmehr Ebrahim*, Fazli Roxana, Gholamhosseyni Maral
* School of Chemistry, College of Science, University of Tehran, Tehran, Iran
In this study, oxidative coupling of pyridine N-oxides with benzofurans has been investigated through palladium-catalyzed oxidative coupling reactions. Benzofuran derivatives, especially 2-aryl benzofurans, exhibit many functional and biological properties such as anticancer, antifungal, and antimalaria activity. These compounds are also used to treat asthma and rheumatism. 2-Pyridyl benzofurans have electroluminescence properties and are used for imaging of beta-amyloid plaques in Alzheimer's disease. In this paper, a series of compounds with anticipated biological properties are prepared with high efficiency by direct formation of a carbon-carbon bond between the two carbon-hydrogen bonds of benzofuran and pyidine N-oxide derivatives bearing electron donating or withdrawing groups, using palladium acetate as a catalyst and copper acetate and bromide as oxidant.
Keyword(s): Oxidative cross coupling reaction,Palladium,Pyridine N-Oxide,Benzofuran
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