Paper Information

Journal:   PROGRESS IN BIOMATERIALS   2018 , Volume 7 , Number 4; Page(s) 269 To 278.
 
Paper: 

Polyurethane synthesis for vascular application

 
 
Author(s):  Zaredar Zahra, ASKARI FAHIMEH*, Shokrolahi Parvin
 
* Polymer Science Department, Iran Polymer and Petrochemical Institute, Tehran, Karaj Hwy, Tehran 14977?13115, Iran
 
Abstract: 
Three polyurethane formulations were prepared on the basis of siloxane; two formulations contained 1% and 3% of a hydroxyl functionalized polyhedral oligomeric silsesquioxane [POSS (ROH)2] nano-particles (as a co-chain extender) and one was without nano-particle. Structures of the polyurethanes were characterized by FTIR and SEM. The effect of POSS nanoparticles on properties of the synthesized PUs was examined for vascular applications by tensile test, contact angle, SEM, AFM and endothelial cells viability evaluation. Properties of the polyurethane with 1% POSS were compared with those of PU without POSS and the results showed 66% increase in the elongation-at-break, 53% increase in tensile strength and 33% increase in modulus, 9. 45% increase in contact angle, 76. 7% reduction in surface roughness and 9. 46% increase in cell viability. It was also shown that a polyurethane containing 1% of POSS nano-particles in its structure developed the highest hydrophobicity, which resulted in its lowest potential for thrombosis.
 
Keyword(s): Vascular applications ·,Polyurethane ·,POSS nano-particles ·,Siloxane macrodiol ·,Biocompatibility
 
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