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Paper Information

Journal:   JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)   fall 2018 , Volume 12 , Number 3 ; Page(s) 15 To 27.

Influence of process parameters on the preparation of porous calcium phosphate granules by rotary oil method

Author(s):  Amirabadi Farahani Mahdi, Mohammadi Zahra*, Sheikh Mehdi Mesgar Abdolreza*
* Bioceramics and Implants Laboratory, Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
In order to prepare spherical calcium phosphate granules for biomedical applications, several methods have been investigated by the researchers. In this study, the spherical granules with a potential for tissue growth and drug carrying were prepared by a process, known as the rotary oil method, which was based on the hydrophilic and olephobic features of calcium phosphate slurry. This process is a simple and fast method to produce the granules with a controllable size and porosity suitable for different applications in the biomedical field. The process was optimized by Taguchi method using a L9 orthogonal array. Four parameters including stirring rate of oil, oil temperature, needle diameter, and weight ratio of gelatin to water, each of them in three levels, were used. The starting calcium phosphate powder was a calcium-deficient hydroxyapatite which was synthesiezed by an alkaline hydrolysis method. The sintered granules and starting podwer were characterized by XRD and SEM. The rotary oil method produced granules with a size in the range of 120-1580 μ m and porosity 35-45% suitable for a range of biomedical applications.
Keyword(s): Biphasic calcium phosphate,Granule,Spherical particles,Porosity,Taguchi method
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