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Paper Information

Journal:   JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)   winter 2019 , Volume 12 , Number 4 #f00656; Page(s) 27 To 35.

Synthesis of two novel chiral ionic liquids based on pyridine from alanine amino acid and evaluation of their antibacterial and antioxidant effects

Author(s):  SHAHVELAYATI ASHRAF SADAT*, Khalil Moghaddam Shiva, Hosseinzadeh Soudeh
* Young Researchers and Elite Club, Yadegar e Imam Khomeini Shahre Rey Azad University, Tehran, Iran
Ionic liquids are remarkable chemical compounds, which find biological applications in addition to solvent role in many areas of modern science. Herein, we describe a simple and effective method to synthesize two kinds of novel chiral ionic liquids based on pyridinium named 1-(4-((1-Carboxyethyl)carbamoyl)benzyl) pyridinium Chloride [CECBPy]Cl and 1-(4-(((1-Carboxyethyl)carbamothioyl)carbamoyl) benzyl) pyridinium chloride [CECTCBPy]Cl in two steps from alanine and their optical rotation properties have been measured by polarimeter instrument. These new ionic liquids were characterized by using IR, 1HNMR, 13CNMR, and MS spectroscopy. Evaluation of the antibacterial effects of synthetic compounds were carried out by determination of minimum inhibitory concentration )MIC) using broth micro-dilution method. Antioxidant activity of samples was measured with 2, 2-diphenyl-1-picrylhydrazyl radical scavenging activity. The results showed 1-(4-(((1-Carboxyethyl)carbamothioyl) carbamoyl) benzyl) pyridinium chloride [CECTCBPy]Cl has the best antioxidant effect.
Keyword(s): Chiral ionic liquids,Pyridine,Antibacterial effect,Antioxidant effect,Biological
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