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Paper Information

Journal:   MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)   2018 , Volume 32 , Number 1; Page(s) 0 To 0.

A double blind randomized clinical trial to investigate the effect of vitamin D supplementation on metabolic and hepato-renal markers in type 2 diabetes and obesity



Author(s):  Safarpour Peivasteh, VAFA MOHAMMAD REZA*, Amiri Fatemeh sadat, JANANI LEILA, Noorbakhsh Mitra, Rajabpour Nikoo Ensieh, SADEGHI HOMA
* Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
Background: According to the recent studies, vitamin D deficiency has been correlated with progress in type 2 Diabetes and Metabolic Syndrome. The aim of this study was to assess the effect of vitamin D supplementation on glucose and lipid profiles, blood pressure, and biomarkers of liver and kidney in type 2 diabetic patients. Methods: In this Double blinded randomized clinical trial, 90 patients with type 2 diabetes and serum 25-Hydroxy vitamin D levels of less than 30 ng/ml recruited from “ Besat Diabetes Clinic” in Rasht, North of Iran. The subjects took 50000 IU vitamin D supplements or placebo for 8 weeks. We assessed the levels of serum 25 (OH) vitamin D, glucose and lipid profiles, oxidative and inflammatory indices, liver and kidney biomarkers, blood pressure, and sun exposure time, physical activity before and after intervention, and compared them between cases and controls. Results: Vitamin D supplementation significantly increased serum vitamin D level, Superoxide Dismutase (SOD) activity, and significantly decreased serum HbA1C (Glycosylated Hemoglobin) level (p<0. 001). High Density Lipoprotein (HDL) Cholesterol increased significantly (p=0. 016), and Erythrocyte Sedimentation Rate (ESR) significantly decreased (p=0. 039) after the intervention. Conclusion: Our results represented that weekly supplementation with 50000 IU vitamin D for 8 weeks may be effective by improving HbA1C and lipid profile in type 2 diabetes mellitus.
Keyword(s): Vitamin D,Glucose,Diabetes,Lipid,Diet,Nutrition,Liver,Kidney,Type 2 diabetes,Inflammation
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