Paper Information

Journal:   MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)   2018 , Volume 32 , Number 1; Page(s) 0 To 0.
 
Paper: 

ATP2B1 rs2681472 and STK39 rs35929607 polymorphisms and risk of Hypertension in Iranian Population

 
 
Author(s):  JAMSHIDI JAVAD, Asnaashari Ali, ALIPOOR REZA, MOHAMMADI SINA, Roostaei Sara, Samadian Mohammad Mahdi, Honarmand Aliabadi Saiedeh, Bahramali Ehsan*
 
* Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran / Department of Cardiology, Fasa University of Medical Sciences, Fasa, Iran
 
Abstract: 
Background: ATP2B1 and STK39 have been introduced as essential hypertension candidate genes. The association of these genes’ variations have not been studied in Iranian population yet. Here we aimed to investigate the association of ATP2B1 rs2681472 and STK39 rs35929607 polymorphisms with the risk of hypertension in an Iranian population. Methods: We included 400 individuals in our case-control study: 200 cases with essential hypertension and 200 healthy sex and age matched controls. All subjects were genotyped for rs2681472 and rs35929607 using a PCR-RFLP method. Genotype and allele frequencies were compared between the two groups using chi-squared test. The association was further assessed under log-additive, dominant and recessive genetic models. Results: There was no association between rs2681472 and rs35929607 polymorphisms and risk of essential hypertension in our population (p>0. 05). There was also no association between the studied polymorphisms and hypertension under different genetic models. Conclusion: Our study indicated that rs2681472 of ATP2B1 and rs35929607 of STK39 may not have a significant effect on the risk of essential hypertension in Iranian population. More studies are still needed to validate our results.
 
Keyword(s): Essential hypertension,ATP2B1,STK39,Polymorphism,Association study
 
References: 
 
  pdf-File tarjomyar Yearly Visit 24
 
Latest on Blog
Enter SID Blog