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Paper Information

Journal:   CASPIAN JOURNAL OF NEUROLOGICAL SCIENCES   April 2019 , Volume 5 , Number 2 (17); Page(s) 96 To 100.

Case Report: Tumefactive Brain Lesions in Patients with Neuromyelitis Optica Spectrum Disorder

Author(s):  Manouchehri Navid, Nehzat Nasim, Mirmosayeb Omid, SHAYGANNEJAD VAHID*, Barzegar Mahdi
* Isfahan Neuroscience Research Center/Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Background: Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune neurological disorder that is characterized by optic neuritis and longitudinally-extended transverse myelitis lesions in spinal segments. Magnetic Resonance Imaging (MRI) findings are part of the diagnostic process in NMOSD patients, and abnormal lesion patterns may cause deviation from a correct diagnosis. Clinical Presentation and Intervention: A 43-year-old female patient with abrupt cognitive loss, motor dysfunction and tumefactive spread of the demyelinating lesions in her brain presented to the Neurology Clinic of Kashani Hospital. Anti Aquaporine 4(AQP-4) antibody was observed, and the patient responded well to the NMOSD treatment. Conclusion: NMOSD can be considered a differential diagnosis during an episode of Fulminant Demyelinating Disorder (FDD) with the tumefactive spread of the lesions.
Keyword(s): Neuromyelitis optica,Magnetic resonance imaging,Brain
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