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Paper Information

Journal:   IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS   January-February 2019 , Volume 34 , Number 6 (92) ; Page(s) 986 To 996.

Simultaneous effects of Calotropis procera (Willd. ) R. Br. dried latex and vitamin C on the serum factors of type 1 diabetic rats

Author(s):  Molaeinejad f., Ezzati Ghadi f.*, Ramezani Ghara A., REZAEI ZARCHI S.
* Department of Plant Biology, Faculty of Sciences, University of Jiroft, Jiroft, Iran
The present study investigates the anti-diabetic properties of dried latex of Calotropis procera (Willd. ) R. Br. with vitamin C in diabetic rats. Thirty adult male Wistar rats were randomly and equally divided into six groups as follow: first group) control, second group) diabetes was induced by a single dose of streptozotocin (50 mg/kg b. w by IP), third group) diabetic rats were treated by 200 mg dried latex per kilogram of body weight, fourth group) the diabetic rats were treated by combined treatments of dried latex (200mg/kg) and vitamin C (100mg/kg) by gavage, fifth group) animals in this group were treated by (200mg/kg) dried latex daily and the sixth group) rats were treated by vitamin C (100mg/kg). After 15 days, the biochemical factors of blood sugar, triglyceride, total cholesterol, and glycated hemoglobin (HbAlc) were evaluated. Results showed that the amount of biochemical factors was increased significantly in the diabetic group. Dried latex and also the combined treatment of dried latex and vitamin C reduced the elevated levels of abovementioned biochemical factors. Moreover, the aqueous extract of dried latex compared to the group four, was more effective. In conclusion, the dried latex of Calotropis procera has anti-diabetic activity.
Keyword(s): Hyperglycemy,hyperlipidemy,Calotropis procera (Willd.) R.Br.,vitamin C
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