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Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   April 2017 , Volume 15 , Number 4; Page(s) 203 To 208.
 
Paper: 

N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT

 
 
Author(s):  BEHROUZI LAK TAHEREH*, HAJSHAFIHA MASOMEH, NANBAKHSH FARIBA, OSHNOUEI SIMA
 
* Department of Obstetrics and Gynecology, Urmia Reproductive Health Research Center, Kashani St., Urmia, Iran
 
Abstract: 
Background: N-acetyl cysteine (NAC) was proposed as an adjuvant to clomiphene citratefor ovulation induction in patients with polycystic ovary syndrome (PCOS) without clomiphene citrate resistance. Objective: To evaluate the effect of NAC on pregnancy rate in PCOS patients who were candidates for intrauterine insemination. Materials and Methods: In this randomized clinical trial 97 PCOS women aged 18-38 years were enrolled in two groups, randomly. For the case group (n=49), NAC (1. 2 gr)+ clomiphene citrate (100 mg) + letrozole (5mg) were prescribed Daily from the third day of menstruation cycle for five days. The control group (n=48) had the same drug regimen without NAC. In order to follicular development, GONALF was injected on days of 7-11 menstrual cycles in all participants. When the follicle size was 18mm or more, HCG (10000 IU) was injected intramuscular and the intrauterine insemination was performed after 34-36 hr. Results: There were not significant differences between study groups regarding mean endometrial thickness (p=0. 14), mean number of mature follicles (p=0. 20) and the pregnancy rate (p=0. 09). Conclusion: NAC is ineffective in inducing or augmenting ovulation in PCOS patients who were candidates for intrauterine insemination and cannot be recommended as an adjuvant to CC in such patients.
 
Keyword(s): N-acetyl cysteine,Polycystic ovary syndrome,Intrauterine insemination,Ovulation induction
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

BEHROUZI LAK, T., & HAJSHAFIHA, M., & NANBAKHSH, F., & OSHNOUEI, S. (2017). N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 15(4), 203-208. https://www.sid.ir/en/journal/ViewPaper.aspx?id=666246



Vancouver: Copy

BEHROUZI LAK TAHEREH, HAJSHAFIHA MASOMEH, NANBAKHSH FARIBA, OSHNOUEI SIMA. N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE). 2017 [cited 2021June24];15(4):203-208. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=666246



IEEE: Copy

BEHROUZI LAK, T., HAJSHAFIHA, M., NANBAKHSH, F., OSHNOUEI, S., 2017. N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), [online] 15(4), pp.203-208. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=666246.



 
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