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Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   november 2016 , Volume 14 , Number 11; Page(s) 687 To 690.
 
Paper: 

Efficacy of Intrauterine infusion of granulocyte colony stimulating factor on patients with history of implantation failure: A randomized control trial

 
 
Author(s):  EFTEKHAR MARYAM, MIRAJ SEPIDEH*, FARID MOJTAHEDI MARYAM, NEGHAB NOSRAT
 
* Department of Obstetrics and Gynecology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
 
Abstract: 
Background: Although pregnancy rate in in vitro fertilization-embryo transfer (IVF-ET) cycles has been increased over the preceding years, but the majority of IVF-ET cycles still fail. Granulocyte colony stimulating factor (GCSF) is a glycoprotein that stimulates cytokine growth factor and induces immune system which may improve pregnancy rate in women with history of implantation failure. Objective: The aim of this study was to evaluate GCSF ability to improve pregnancy rate in women with history of implantation failure Materials and Methods: 0. 5 ml (300 μ g/ml) GCSF was infused intrauterine in intervention group. Pregnancy outcomes were assessed based on clinical pregnancy. Results: The mean age of participants was 31. 95± 4. 71 years old. There were no significant differences between demographic characteristics in two groups (p>0. 05). The pregnancy outcome in GCSF group was improved significantly (p=0. 043). Conclusion: GCSF can improve pregnancy outcome in patients with history of implantation failure.
 
Keyword(s): GCSF,Pregnancy rate,In vitro fertilization
 
References: 
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