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| Journal:
INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)
August 2018
, Volume 16
, Number 8; Page(s) 529 To 534. |
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Paper: Influence of body mass index and polycystic ovarian syndrome on ICSI/IVF treatment outcomes: A study conducted in Pakistani women |
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| Author(s): REHMAN REHANA, Mehmood Mohsin, Ali Rabiya, Shaharyar Saeeda, ALAM FAIZA* |
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| * Department of Biological and Biomedical Sciences, Faculty of Health Sciences, Medical College, The Aga Khan University, Stadium Road, Karachi, Pakistan |
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| Abstract:
Background: Obesity may establish a crucial barrier for effective fertility treatment in polycystic ovary syndrome (PCOS) females. Objective: To compare results of intra-cytoplasmic sperm injection (ICSI) in females with and without polycystic ovarian syndrome and further appraise the effect of obesity in PCOS females. Materials and Methods: A cross-sectional study from June 2015 to July 2016 included non-PCOS and PCOS (recognized by Rotterdam criteria) females who underwent ICSI. The PCOS were further stratified into non-obese and Obese according to the South Asian criteria for body mass index. Results were categorized on the basis of beta-human chorionic gonadotropin (β-hCG) and transvaginal scan into non-pregnant (β-hCG <25 mIU/ml), preclinical abortion (β-hCG >25 mIU/ml with no fetal cardiac activity) and clinical pregnancy (β-hCG >25 mIU/ml with fetal cardiac activity on transvaginal scan). In addition, reproductive outcomes; implantation rate, clinical pregnancy rate and miscarriage rate among obese and non-obese PCOS and non-PCOS patients were compared. Results: Our results revealed 38. 5% clinical pregnancy rate in non-PCOs females, 23. 8% in non-obese PCOS females whereas 26. 4% in obese PCOS. Preclinical abortions were found to be highest (31. 5%) in non-obese PCOS females and were the lowest (26. 2%) in non-PCOS females. In non-PCOS group and non-obese PCOS females 35. 4% and 44. 6%, respectively, failed to become pregnant. Conclusion: The success after ICSI in terms of number of clinical pregnancies was more in non-PCOS patients as compared to PCOS. Increase in body mass index reflected a negative impact on the reproductive outcome in PCOS patients.
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| Keyword(s): Quetelet’s index,Obesity,Polycystic ovary syndrome,Sperm injection,Intracytoplasmic,Infertility |
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