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Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   August 2018 , Volume 16 , Number 8; Page(s) 497 To 500.
 
Paper: 

Antioxidant homeostasis is disturbed in fetuses with leptin-resistant genotypes: A cross-sectional study

 
 
Author(s):  Gonzalez Anover Pedro, Torres Rovira Laura, Garcia Contreras Consolacion, Vazquez Gomez Marta, Pesantez Jose Luis, Sanz Fernandez Maria Victoria, Astiz Susana, Gonzalez Bulnes Antonio*
 
* Comparative Physiology Group, SGIT-INIA, Avda. Puerta de Hierro s/n. 28040 Madrid, Spain
 
Abstract: 
Background: Leptin resistance is associated with lower reproductive efficiency, with deficiencies in embryo viability and growth leading to low prolificacy and high incidence of intrauterine growth restriction. Objective: We aimed to investigate the underlying mechanisms of the leptin-resistance, evaluating the antioxidant homeostasis of leptin-resistant and lean swine fetuses. Materials and Methods: The study included 70 plasma samples from fetuses at day 62 of gestation (mid-pregnancy), from breeds with (Iberian breed; n=35) and without leptin resistance (25% Large White x 25% Landrace x 50% Pietrain; n=35). The antioxidant status of the plasma samples was determined by photoinduced chemiluminescence whilst systemic oxidative stress was assessed determining plasma hydrogen peroxide concentration by enzimoimmunoassay. Results: Plasma total antioxidant capacity was significantly lower in leptin-resistant fetuses (p=0. 003), whilst systemic oxidative stress was increased (p=0. 02). Conclusion: Our results indicate key differences in the antioxidant status in pregnancies affected by leptin resistance.
 
Keyword(s): Animal models,Fetus,Leptin,Oxidative stress,Pregnancy
 
 
References: 
 
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APA: Copy

Gonzalez Anover, P., & Torres Rovira, L., & Garcia Contreras, C., & Vazquez Gomez, M., & Pesantez, J., & Sanz Fernandez, M., & Astiz, S., & Gonzalez Bulnes, A. (2018). Antioxidant homeostasis is disturbed in fetuses with leptin-resistant genotypes: A cross-sectional study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(8), 497-500. https://www.sid.ir/en/journal/ViewPaper.aspx?id=666143



Vancouver: Copy

Gonzalez Anover Pedro, Torres Rovira Laura, Garcia Contreras Consolacion, Vazquez Gomez Marta, Pesantez Jose Luis, Sanz Fernandez Maria Victoria, Astiz Susana, Gonzalez Bulnes Antonio. Antioxidant homeostasis is disturbed in fetuses with leptin-resistant genotypes: A cross-sectional study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE). 2018 [cited 2021June22];16(8):497-500. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=666143



IEEE: Copy

Gonzalez Anover, P., Torres Rovira, L., Garcia Contreras, C., Vazquez Gomez, M., Pesantez, J., Sanz Fernandez, M., Astiz, S., Gonzalez Bulnes, A., 2018. Antioxidant homeostasis is disturbed in fetuses with leptin-resistant genotypes: A cross-sectional study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), [online] 16(8), pp.497-500. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=666143.



 
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