Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   August 2018 , Volume 16 , Number 8; Page(s) 497 To 500.
 
Paper: 

Antioxidant homeostasis is disturbed in fetuses with leptin-resistant genotypes: A cross-sectional study

 
 
Author(s):  Gonzalez Anover Pedro, Torres Rovira Laura, Garcia Contreras Consolacion, Vazquez Gomez Marta, Pesantez Jose Luis, Sanz Fernandez Maria Victoria, Astiz Susana, Gonzalez Bulnes Antonio*
 
* Comparative Physiology Group, SGIT-INIA, Avda. Puerta de Hierro s/n. 28040 Madrid, Spain
 
Abstract: 
Background: Leptin resistance is associated with lower reproductive efficiency, with deficiencies in embryo viability and growth leading to low prolificacy and high incidence of intrauterine growth restriction. Objective: We aimed to investigate the underlying mechanisms of the leptin-resistance, evaluating the antioxidant homeostasis of leptin-resistant and lean swine fetuses. Materials and Methods: The study included 70 plasma samples from fetuses at day 62 of gestation (mid-pregnancy), from breeds with (Iberian breed; n=35) and without leptin resistance (25% Large White x 25% Landrace x 50% Pietrain; n=35). The antioxidant status of the plasma samples was determined by photoinduced chemiluminescence whilst systemic oxidative stress was assessed determining plasma hydrogen peroxide concentration by enzimoimmunoassay. Results: Plasma total antioxidant capacity was significantly lower in leptin-resistant fetuses (p=0. 003), whilst systemic oxidative stress was increased (p=0. 02). Conclusion: Our results indicate key differences in the antioxidant status in pregnancies affected by leptin resistance.
 
Keyword(s): Animal models,Fetus,Leptin,Oxidative stress,Pregnancy
 
References: 
 
  pdf-File tarjomyar Yearly Visit 73
 
Latest on Blog
Enter SID Blog