Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   March 2017 , Volume 15 , Number 3; Page(s) 155 To 160.
 
Paper: 

Serum ferritin concentration in early pregnancy and risk of subsequent development of gestational diabetes: A prospective study

 
 
Author(s):  SOHEILYKHAH SEDIGHEH*, MOJIBIAN MAHDIEH, JANNATI MOGHADAM MARYAM
 
* Endocrine Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran/ Shahid Sadoughi Hospital, Shahid Ghandi Blvd., Yazd , Iran
 
Abstract: 
Background: Elevated serum ferritin concentration is associated with insulin resistance and diabetes. Recently it has also been described in gestational diabetes mellitus (GDM). Objective: A prospective study was done to determine whether there was a relationship between serum ferritin concentration in early pregnancy and the risk of GDM. Materials and Methods: A study was performed on 1, 384 pregnant women with gestational age of 12-16 weeks. A blood sample was obtained for measurement of ferritin in the first trimester. Diagnosis of GDM was done by 75 gr oral glucose tolerance test between 24-28 wk. Results: Women who developed GDM had a higher concentration of serum ferritin than women who did not develop GDM (p=0. 01). A ferritin concentration of 45 ng/ml was calculated to be the 75th percentile for healthy pregnant women. Considering this level 32% in the GDM group and 25. 2%of normal subjects exhibited high ferritin levels (p=0. 01). The risk of GDM with these high levels of ferritin was 1. 4-fold higher than that for subjects with lower concentrations. The Odds Ratio was 1. 4 (95% CI= 1-1. 87) (p=0. 01). After adjusted for age Odds Ratio was 1. 38 (95% CI=1. 02-1. 86) (p=0. 03) and after adjustment for pre-pregnancy Body Mass index, the adjusted odds ratio was 1. 31 (CI= 0. 96-1. 79) (p=0. 08). After multivariable adjustment (age and body mass index), the adjusted odds ratio was 1. 3 (0. 95-1. 8) (p=0. 09). Conclusion: High serum ferritin can be regarded as a significant risk factor for the development of gestational diabetes.
 
Keyword(s): Ferritin,Gestational Diabetes
 
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