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| Journal:
INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)
DECEMBER 2017
, Volume 15
, Number 12; Page(s) 803 To 806. |
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Paper: Successful pregnancy and live birth after intrauterine administration of autologous platelet-rich plasma in a woman with recurrent implantation failure: A case report |
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| Author(s): FARIMANI MARZIE, POOROLAJAL JALAL, RABIEE SOGHRA, BAHMANZADEH MARYAM* |
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| * Endometrium and Endometriosis
Research Center, Hamadan
University of Medical Sciences,
Shahid Fahmideh Ave., Hamadan,
Iran. Postal code: 6517838695 |
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| Abstract:
Background: Platelets contain a significant amount of growth factors that have positive effects on local tissue repair and endometrial receptivity. Case: Here we present a 45-yr-old woman with primary infertility and two failed in vitro fertilization (IVF) cycles who was candidate to receive donor eggs. Five consecutive frozen-thawed embryo transfer cycles with good quality embryos were performed within 2 yr. With the diagnosis of recurrent implantation failure (RIF), the patient was treated for improving endometrial receptivity with intrauterine administration of autologous platelet-rich plasma (PRP), 24 hr before embryo transfer. The patient gave birth to a healthy baby boy weighing 2350 gr in the cesarean section. Conclusion: Extensive literature search suggests that this is the first successful pregnancy after administration of PRP in a woman with RIF. Local administration of PRP before embryo transfer may play a vital role in successful implantation.
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| Keyword(s): Recurrent implantation failure,Platelet-rich plasma,Embryo transfer,Assisted reproductive technology,Pregnancy outcome,Embryo implantation |
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