Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   DECEMBER 2017 , Volume 15 , Number 12; Page(s) 803 To 806.
 
Paper: 

Successful pregnancy and live birth after intrauterine administration of autologous platelet-rich plasma in a woman with recurrent implantation failure: A case report

 
 
Author(s):  FARIMANI MARZIE, POOROLAJAL JALAL, RABIEE SOGHRA, BAHMANZADEH MARYAM*
 
* Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Shahid Fahmideh Ave., Hamadan, Iran. Postal code: 6517838695
 
Abstract: 
Background: Platelets contain a significant amount of growth factors that have positive effects on local tissue repair and endometrial receptivity. Case: Here we present a 45-yr-old woman with primary infertility and two failed in vitro fertilization (IVF) cycles who was candidate to receive donor eggs. Five consecutive frozen-thawed embryo transfer cycles with good quality embryos were performed within 2 yr. With the diagnosis of recurrent implantation failure (RIF), the patient was treated for improving endometrial receptivity with intrauterine administration of autologous platelet-rich plasma (PRP), 24 hr before embryo transfer. The patient gave birth to a healthy baby boy weighing 2350 gr in the cesarean section. Conclusion: Extensive literature search suggests that this is the first successful pregnancy after administration of PRP in a woman with RIF. Local administration of PRP before embryo transfer may play a vital role in successful implantation.
 
Keyword(s): Recurrent implantation failure,Platelet-rich plasma,Embryo transfer,Assisted reproductive technology,Pregnancy outcome,Embryo implantation
 
References: 
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