Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   OCTOBER 2017 , Volume 15 , Number 10; Page(s) 635 To 640.
 
Paper: 

The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial

 
 
Author(s):  MESDAGHINIA ELAHEH, Mohammad Ebrahimi Behnaz, FOROOZANFARD FATEMEH, BANAFSHE HAMID REZA*
 
* Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Ravand street, Kashan, Iran
 
Abstract: 
Background: Recurrent spontaneous abortion has high incidence rate. The etiology is unknown in 30-40%. However high uterine artery resistance is accounted as one of the recurrent abortion reasons. Objective: The objective of the current study was to determine the impacts of vitamin E and aspirin on the uterine artery blood flow in women having recurrent abortions due to impaired uterine blood flow. Materials and Methods: This randomized clinical trial was conducted on 99 women having uterine pulsatility index (PI) more than 2. 5 and the history of more than two times abortions. The candidates were categorized into three groups; receiving aspirin, only vitamin E, and aspirin+vitamin E. After 2 months, uterine PIs were compared with each other. Results: All drug regimens caused an enhancement in uterine perfusion with a significant decline in uterine artery PI value. The women receiving vitamin E in accompanied with aspirin had the least mean PI of the uterine artery (p<0. 001). The total average PI score of the right and left uterine arteries in groups receiving vitamin E in accompanied with aspirin was lower than the two counterparts significantly (p<0. 001). Conclusion: Vitamin E, aspirin and especially their combination are effective in improving uterine artery blood flow in women with recurrent abortion due to impaired uterine blood flow. More well-designed studies are needed to find out whether the enhancement of uterine perfusion may lead to a better pregnancy outcome.
 
Keyword(s): Recurrent abortion,Aspirin,Vitamin E,Pulsatility index
 
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