Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   OCTOBER 2017 , Volume 15 , Number 10; Page(s) 601 To 612.
 
Paper: 

Reconstruction of mammalian oocytes by germinal vesicle transfer: A systematic review

 
 
Author(s):  DARBANDI SARA, DARBANDI MAHSA, KHORRAM KHORSHID HAMID REZA, SHIRAZI ABOLFAZL, SADEGHI MOHAMMAD REZA, AGARWAL ASHOK, AL HASANI SAFAA, NADERI MOHAMMAD MEHDI, Ayaz Ahmet, AKHONDI MOHAMMAD MEHDI*
 
* Developmental Biology (Embryology), Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran. Postal code: 1177-19615
 
Abstract: 
Nuclear transfer procedures have been recently applied for clinical and research targets as a novel assisted reproductive technique and were used for increasing the oocyte activity during its growth and maturation. In this review, we summarized the nuclear transfer technique for germinal vesicle stage oocytes to reconstruct the maturation of them. Our study covered publications between 1966 and August 2017. In result utilized germinal vesicle transfer techniques, fusion, and fertilization survival rate on five different mammalian species are discussed, regarding their potential clinical application. It seems that with a study on this method, there is real hope for effective treatments of old oocytes or oocytes containing mitochondrial problems in the near future.
 
Keyword(s): Germinal vesicle,Micromanipulation,Nuclear transfer,Oocyte
 
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