Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   July 2018 , Volume 16 , Number 7; Page(s) 443 To 446.
 
Paper: 

Frequency of cytomegalovirus in fertile and infertile men, referring to Afzalipour Hospital IVF Research Center, Kerman, IRAN: A case-control study

 
 
Author(s):  MOHSENI MAJID, Mollaei Hamidreza*, Arabzadeh Seyed Alimohammad, Mirshekari Tooraj Reza, Ghorbani Peyman
 
* Department of Medical Microbiology, Kerman University of Medical Sciences, Kerman, Iran
 
Abstract: 
Background: Cytomegalovirus (CMV) virus can hide in urinary genital tract cells and affect male infertility disorders. Objective: To evaluate frequency of CMV in the semen samples of men with infertility problems referring to a in vitro fertilization (IVF) center in Kerman, Iran and its association with the parameters of semen. Materials and Methods: In this case-control study, Real time polymerase chain reaction test was performed for detection of human cytomegalovirus in 100 fertile men compared to 100 infertile men referred to the IVF center of Afzalipour Hospital, Kerman, Iran. Results: Out of 200 samples, 30 samples (15%) were positive for CMV DNA virus (23/100 men (23%) in case group and 7/100 men (7%) in the control group). Sperm counts and motility in the control group were more than the case group (p˂ 0. 0001). There was a significant relationship between the prevalence of CMV infection and male infertility (p˂ 0. 001). Conclusion: Our finding showed that, prevalence of CMV infection was higher in infertile men compared to fertile men and CMV infection can be considered as an important part of male infertility. So; antiviral treatment of positive cases can be effective in improving sperm quality and successful IVF. The relationship between CMV infection in semen and infertility was obtained in previous studies and was confirmed by our study.
 
Keyword(s): Infertility,Cytomegalovirus,In vitro fertilization,Real time PCR
 
References: 
 
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