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Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   October 2018 , Volume 16 , Number 10; Page(s) 637 To 640.
 
Paper: 

Relationship between MspI polymorphism of CYP1A1 gene and the risk of endometriosis in an Iranian population: A case-control study

 
 
Author(s):  Babaki Azam, ZARE MEHRJARDI EHSAN, DEHGHANI FIROUZABADI RAZIEH, AFLATOONIAN ABBAS, SEIFATI SEYED MORTEZA*
 
* Medical Biotechnology Research Center, Ashkezar Azad University, Ashkezar, Yazd, Iran, Postal Code: 8941698480
 
Abstract: 
Background: Endometriosis is a disease that affects women of reproductive age. This disease is characterized by the presence of endometrial-like tissues (endometrial or stromal glands) outside the uterus and shows significantly elevated prevalence in industrial regions. Additionally, an interaction between genetics and environmental factors is assumed for the disease. Enzymes belonging to the cytochrome P450 (CYP) family are participated in detoxification process of a wide range of environmental toxins and carcinogens. Thereby, they are good link for the interaction. CYP1A1 which belong to cytochrome P450 (CYPs) superfamily, is a very important gene for the metabolism of carcinogens. Objective: The aim of this study was to analyze the frequency of the MspI polymorphism of CYP1A1 gene and its relation to endometriosis. Materials and Methods: Genomic DNA was isolated from 93 endometriosis women and 139 healthy controls. Genotyping was performed using polymerase chain reaction followed by restriction fragment length polymorphism analysis. Results: Frequencies of the TT, TC, and CC genotype of CYP1A1 gene polymorphism in patients were 73. 1%, 22. 6%, and 4. 3%, while frequencies in controls were 74. 1%, 22. 3%, and 3. 6%, respectively. So there was no significant differences between the genotypes in two groups (p=0. 961). Conclusion: According to our study, MspI polymorphism of CYP1A1 gene appears to be not associated with the risk of endometriosis in the studied population. However, additional studies, especially with larger sample size are needed to validate these findings.
 
Keyword(s): Endometriosis,Cytochrome P-450 CYP1A1,MspI endonuclease
 
 
References: 
 
Click to Cite.
APA: Copy

Babaki, A., & ZARE MEHRJARDI, E., & DEHGHANI FIROUZABADI, R., & AFLATOONIAN, A., & SEIFATI, S. (2018). Relationship between MspI polymorphism of CYP1A1 gene and the risk of endometriosis in an Iranian population: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(10), 637-640. https://www.sid.ir/en/journal/ViewPaper.aspx?id=665491



Vancouver: Copy

Babaki Azam, ZARE MEHRJARDI EHSAN, DEHGHANI FIROUZABADI RAZIEH, AFLATOONIAN ABBAS, SEIFATI SEYED MORTEZA. Relationship between MspI polymorphism of CYP1A1 gene and the risk of endometriosis in an Iranian population: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE). 2018 [cited 2021May11];16(10):637-640. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=665491



IEEE: Copy

Babaki, A., ZARE MEHRJARDI, E., DEHGHANI FIROUZABADI, R., AFLATOONIAN, A., SEIFATI, S., 2018. Relationship between MspI polymorphism of CYP1A1 gene and the risk of endometriosis in an Iranian population: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), [online] 16(10), pp.637-640. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=665491.



 
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