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Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   November 2018 , Volume 16 , Number 11; Page(s) 679 To 682.
 
Paper: 

The correlation between insulin-like growth factor binding protein 1 (IGFBP-1) and homeostasis model assessment of insulin resistance (HOMA-IR) in polycystic ovarian syndrome with insulin resistance

 
 
Author(s):  Firmansyah Arini, Chalid Maisuri Tadjuddin*, Farid Retno Budiati, Abdullah Nusratuddin
 
* Department of Obstetrics and Gynecology Faculty of Medicine Universitas Hasanuddin Makassar, Indonesia, 90245
 
Abstract: 
Background: The underlying etiology of polycystic ovarian syndrome (PCOS) is unknown and assumed to have a strong correlation with insulin resistance. Homeostasis Model Assessment of insulin resistance (HOMA-IR) is a good tool to assess insulin resistance. Low levels of serum Insulin-like Growth Factor-Binding Protein-1 (IGFBP-1) in PCOS women led to the hypothesis that hyperinsulinemia in PCOS inhibits the production of IGFBP-1, which in turn stimulates excessive androgen production. Objective: The study is aimed to analyze the correlation between the levels of IGFBP-1 and HOMA-IR on insulin resistance in PCOS. Materials and Methods: A cross-sectional study among 105 PCOS women, including 60 women with insulin resistance were recruited. The mean of IGFBP-1 and HOMA-IR were 6. 507± 4. 7821 μ g/l and 3. 633± 1. 666 respectively. Results: Low levels of IGFBP-1 were detected in all insulin resistance women. There was a correlation between HOMA-IR and overweight (p=0. 045), while IGFBP-1 showed no correlation with overweight (p=0. 106). In addition, no correlation between IGFBP-1 with HOMA-IR as a marker of insulin resistance was detected. Conclusion: Despite the decrease in IGFBP-1, it seems that there is no correlation between IGFBP-1 with HOMA-IR as a marker of insulin resistance.
 
Keyword(s): Insulin-like growth factor binding protein 1,Insulin resistance,Polycystic ovarian syndrome
 
 
References: 
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Click to Cite.
APA: Copy

Firmansyah, A., & Chalid, M., & Farid, R., & Abdullah, N. (2018). The correlation between insulin-like growth factor binding protein 1 (IGFBP-1) and homeostasis model assessment of insulin resistance (HOMA-IR) in polycystic ovarian syndrome with insulin resistance. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(11), 679-682. https://www.sid.ir/en/journal/ViewPaper.aspx?id=665442



Vancouver: Copy

Firmansyah Arini, Chalid Maisuri Tadjuddin, Farid Retno Budiati, Abdullah Nusratuddin. The correlation between insulin-like growth factor binding protein 1 (IGFBP-1) and homeostasis model assessment of insulin resistance (HOMA-IR) in polycystic ovarian syndrome with insulin resistance. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE). 2018 [cited 2021May14];16(11):679-682. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=665442



IEEE: Copy

Firmansyah, A., Chalid, M., Farid, R., Abdullah, N., 2018. The correlation between insulin-like growth factor binding protein 1 (IGFBP-1) and homeostasis model assessment of insulin resistance (HOMA-IR) in polycystic ovarian syndrome with insulin resistance. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), [online] 16(11), pp.679-682. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=665442.



 
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