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Paper Information

Journal:   MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)   2017 , Volume 31 , Number 1; Page(s) 0 To 0.

Study of Porphyromonas gingivalis in periodontal diseases: A systematic review and meta-analysis

* Department of Immunology and Microbiology, Dezful University of Medical Sciences, Dezful, Iran
Background: The mouth cavity hosts various types of anaerobic bacteria including Porphyromonas gingivalis, which causes periodontal inflammatory diseases. P. gingivalis is a gram-negative oral anaerobe and is considered as a main etiological factor in periodontal diseases. Several studies have reported a relationship between P. gingivalis in individuals with periodontal diseases and a critical role of this bacterium in the pathogenesis of periodontal diseases. The present study aimed at estimating this probability using a meta-analysis. Methods: We searched several databases including PubMed, Scopus, Google Scholar, and Web of Science to identify case-control studies addressing the relationship between P. gingivalis with periodontal diseases. A total of 49 reports published from different countries from 1993 to 2014 were included in this study. I² (heterogeneity index) statistics were calculated to examine heterogeneity. Data were analyzed using STATA Version 11. Results: After a detailed analysis of the selected articles, 49 case-control studies with 5924 individuals fulfilled the inclusion criteria for the meta-analysis. The healthy controls included 2600 healthy individuals with a Mean± SD age of 36. 56± 7. 45 years. The periodontal diseases group included 3356 patients with a mean age of 43. 62± 8. 35 years. There was a statistically significant difference between P. gingivalis in periodontal patients and healthy controls; 9. 24 (95% CI: 5. 78 to 14. 77; P = 0. 000). In the other word, there was a significant relationship between the presence of P. gingivalis and periodontal diseases. Conclusion: Analyzing the results of the present study, we found a strong association between the presence of P. gingivalis and periodontal diseases. This result suggests that another research is needed to further assess this subject.
Keyword(s): Porphyromonas gingivalis,Periodontal Diseases,Chronic Periodontitis,Aggressive Periodontitis,Gingivitis
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