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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   February 2019 , Volume 22 , Number 2; Page(s) 76 To 79.
 
Paper: 

Hepatitis C (HCV) Viremic Rate and its Correlation to Demographic Factors among HCV Confirmed Iranian Blood Donors

 
 
Author(s):  Ranjbar Kermani Fahimeh, MOUSAVI HOSSEINI KAMRAN*, Amini Kafi Abad Sedigheh, MANSOURNIA MOHAMMAD ALI, SHARIFI ZOHREH, MAGHSUDLU MAHTAB
 
* Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran/ IBTO building, Hemmat Express Way, adjacent to the Milad Tower, Tehran, Iran
 
Abstract: 
Background: Hepatitis C virus (HCV) viremia is described as persistent HCV RNA among HCV exposed individuals. HCV viremic rate is defined as the proportion of anti-HCV positive and HCV RNA positive individuals to total anti-HCV positive individuals. Knowledge about HCV viremic rate increases understanding HCV epidemiology and provides the likelihood of HCV viremia infection in a given population. The aim of this study was to evaluate HCV viremic rate and demographic parameter correlations among HCV confirmed Iranian blood donors. Methods: In this analytical, cross-sectional study, serologically confirmed HCV positive blood donors, who were referred to the Iranian blood transfusion centers around the country from November 2015 to September 2017, were included. HCV RNA RT-PCR was carried out by an in-house qualitative assay. Penalized logistic regression was performed for data analysis. STATA software version 13 was used for statistical analysis. Results: Out of 239 subjects, HCV RNA was amplified in 161 (67. 36%, 95% CI 61. 21%-73. 51%). No statistical associations were found between age, gender, education and marriage status with HCV viremic rate. First time donation was found to be associated with HCV viremia status (adjusted odds ratio [AOR]: 3. 26; 95% CI 1. 07– 9. 87). Conclusion: The results of this study show the likelihood of active HCV infection occurrence among HCV confirmed Iranian blood donors, as the majority are in the active phase of HCV infection. The viremic rate was associated with first time donation. More effective donor selection process and paying special attention to maintenance of non-infected first time donors as a resource of regular donations are needed to improve blood safety. Follow-up studies on viremic first time blood donors are recommended to clarify impact of factors on the occurrence of HCV viremia.
 
Keyword(s): Blood donors,Hepatitis C,Viremia
 
References: 
 
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