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Paper Information

Journal:   MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)   2017 , Volume 31 , Number 1; Page(s) 0 To 0.
 
Paper: 

Comparison of intramuscular progesterone with oral nifedipine for treating threatened preterm labor: A randomized controlled trial

 
DOI: 

10.14196/mjiri.31.56

 
Author(s):  HAGHIGHI LADAN, RASHIDI MANDANA, NAJMI ZAHRA*, Homam Homa, HASHEMI NEDA, MOBASSERI ALIREZA, MORADI YOUSEF
 
* Zanjan University of Medical Sciences, Zanjan, Iran
 
Abstract: 
Background: Threatened preterm labor (TPL) is the leading cause of hospitalization during pregnancy. Tocolytic agents are the primary therapeutic options for TPL. The aim of this study is to compare intramuscular progesterone with oral nifedipine as a tocolytic agent. Methods: This randomized controlled trial was carried out in a teaching hospital (Shahid Akbarabadi) in Tehran, Iran, from December 2011 to November 2012. Three hundred and fifteen singleton pregnant women aged >18 yrs at 26-34 weeks’ gestation with the diagnosis of threatened preterm labor (TPL) were randomly received either intramuscular progesterone or oral nifedipine for tocolysis. Maternal and neonatal outcomes were then compared between the two interventions. P value less than 0. 05 was considered statistically significant. IRCT registration number of this study is IRCT201112198469N1 Results: The success rate of progesterone and nifedipine in treating TPL were 83% and 82. 7%, respectively. There was no significant difference between the two interventions with regard to gestational age at delivery, type of delivery, the time interval until the delivery, birth weight, NICU admission rate and hospital stays. Progesterone administration was associated with lower duration of NICU stay as compared with nifedipine (0. 33± 0. 77 days vs. 1. 5± 3. 2 days, p<0. 05). None of the two drugs caused any major side effects. Conclusion: Single dose intramuscular progesterone is as effective as oral nifedipine in treating TPL. It also significantly reduces the NICU stay.
 
Keyword(s): Progesterone,Nifedipine,Threatened preterm labor
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

HAGHIGHI, L., & RASHIDI, M., & NAJMI, Z., & Homam, H., & HASHEMI, N., & MOBASSERI, A., & MORADI, Y. (2017). Comparison of intramuscular progesterone with oral nifedipine for treating threatened preterm labor: A randomized controlled trial. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 31(1), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=665281



Vancouver: Copy

HAGHIGHI LADAN, RASHIDI MANDANA, NAJMI ZAHRA, Homam Homa, HASHEMI NEDA, MOBASSERI ALIREZA, MORADI YOUSEF. Comparison of intramuscular progesterone with oral nifedipine for treating threatened preterm labor: A randomized controlled trial. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI). 2017 [cited 2021June24];31(1):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=665281



IEEE: Copy

HAGHIGHI, L., RASHIDI, M., NAJMI, Z., Homam, H., HASHEMI, N., MOBASSERI, A., MORADI, Y., 2017. Comparison of intramuscular progesterone with oral nifedipine for treating threatened preterm labor: A randomized controlled trial. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), [online] 31(1), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=665281.



 
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