Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   MAY 2019 , Volume 17 , Number 5; Page(s) 303 To 314.
 
Paper: 

Interleukins in diagnosis of perinatal asphyxia: A systematic review

 
DOI: 

10.18502/ijrm.v17i5.4598

 
Author(s):  BOSKABADI HASSAN, MORADI ALI, ZAKERIHAMIDI MARYAM*
 
* Department of Midwifery, Faculty of Medical Sciences, Tonekabon Azad University, Tonekabon, Iran, Postal Code: 4661734666
 
Abstract: 
Background: Biochemical markers including interleukins (ILs) has been proposed for early diagnosis of asphyxia. Objective: This study has aimed to systematically review the significance of IL measurements in the diagnosis of perinatal asphyxia. Materials and Methods: PubMed, Cochrane Library, Web of Science, Embase, and Scopus databases before 2017 were searched for the following keywords: asphyxia, neonatal, interleukin, and diagnosis. A total of 13 out of 300 searched papers were finally selected for evaluation. Interleukins under study were IL6 and interleukin 1𝛽 (IL-1𝛽 ). Interleukins had been measured in 10 studies by serum samples, 2 studies by samples of Cerebro Spinal Fluid (CSF), and 1 study by sample of umbilical cord blood. The inclusion criteria were: studies on neonates, with adequate information from the test results and studies using markers other than ILs to detect asphyxia; however, studies with only abstracts available were excluded. Results: Research on the issue suggests that IL6 > 41 Pg/dl has the sensitivity of 84. 88% and the specificity of 85. 43%, whereas IL-1𝛽 > 4. 7 Pg/dl has the sensitivity of 78% and specificity of 83% in the diagnosis of neonatal asphyxia. Among diagnostic ILs for neonatal asphyxia, combination of IL6 and IL-1𝛽 had the highest sensitivity, that is, 92. 9%. Conclusion: IL6 and IL-1𝛽 of serum samples were used in the early diagnosis of perinatal asphyxia and are useful predictors for the outcomes of perinatal asphyxia and its intensity. In addition, simultaneous evaluation of IL-1𝛽 and IL6 can improve the sensitivity of the early diagnosis of perinatal asphyxia.
 
Keyword(s): Diagnosis,Interleukins,Asphyxia neonatorum
 
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