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Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   January 2018 , Volume 16 , Number 1; Page(s) 19 To 30.
 
Paper: 

Resveratrol supplementation rescues pool of growing follicles and ovarian stroma from Cisplatin-induced toxicity on the ovary in Sprague-Dawley rats: An experimental study

 
 
Author(s):  Chinwe Gbotolorun Stella*, Azuka Okafor Izuchukwu, Adaeze Ndoeche Chidinma
 
* Anatomy Department, Faculty of Basic Medical Sciences, College of Medicine of the University of Lagos, Idiaraba Campus, P.M.B 12003, Lagos, Nigeria
 
Abstract: 
Background: Cisplatin is a potent antineoplastic agent for many cancers but causes several levels of gonadal damage. Ovarian toxicity is a major concern of young cancer patients undergoing chemotherapy. Objective: This study sought to examine the effect of Cisplatin and Resveratrol supplementation on ovarian function in Sprague-Dawley rats. Materials and Methods: In this experimental study, 45 cyclic Sprague-Dawley rats with an average weight of 160 gr were divided into 9 groups (n=5/group). Group 1 was used as control and received distilled water. Groups 2 and 9 received Cisplatin only. Groups 3, 4, and 5 received different doses of Resveratrol after a single dose of Cisplatin. Groups 6, 7, and 8 received Resveratrol before Cisplatin. At sacrifice, the ovary was analyzed for histopathology, biochemical indices of oxidation and hormonal assay. Results: Relative and absolute organ weights were notably increased (p=0. 001, 0. 01) in the prophylactic groups relative to the groups that received Resveratrol after Cisplatin. Also, glutathione, superoxide dismutase and catalase were significantly increased (p=0. 047, 0. 01, 0. 023) in a dose-dependent manner when compared to Cisplatin group only. Malondialdehyde decreased significantly (p=0. 001) in the groups that received high dose Resveratrol compared with the control and Cisplatin alone groups. Although oestrogen showed no significant difference within the groups (p=0. 48), Resveratrol significantly increased progesterone, follicle stimulating hormone and luteinizing hormone levels (p=0. 007, 0. 001, 0. 006) at high doses when compared with Cisplatin alone groups. Ovarian histoarchitecture was best preserved in the prophylactic groups in a dose-dependent manner. Conclusion: Resveratrol supplementation confers protection and preserves ovarian follicles from Cisplatin toxicity in Sprague-Dawley rats.
 
Keyword(s): Cisplatin,Ovary,Resveratrol,Sprague-Dawley rat
 
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