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Paper Information

Journal:   IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS   July-August 2018 , Volume 34 , Number 3 (89) #M00573; Page(s) 527 To 534.
 
Paper: 

Antinociceptive (acetic acid test) and anti-inflammatory effects of Satureja bachtiarica Bunge essential oil in male mice

 
 
Author(s):  Tajmirali Sh., Setorki M.*, HOOSHMANDI Z.
 
* Department of Biology, Izeh Azad University, Izeh, Iran
 
Abstract: 
Given the role of inflammation and pain, causing delayed diseases recovery, as well as the side effects of chemical drugs and traditional uses of Satureja bachtiarica Bunge, this study was aimed to evaluate the analgesic and anti-inflammatory effects of S. bachtiarica essential oil. In this experimental study, analgesic and anti-inflammatory effects of S. bachtiarica essential oil were evaluated using acetic acid and xylene tests. In each test, male NMRI mice were randomly divided into five groups including control (normal saline, IP), positive control (indomethacin at a dose of 10 mg/kg/dexamethasone at a dose of 2mg/kg, IP) and intervention groups (Satureja bachtiarica essential oil at doses of 50, 75 and 100 mg/kg, IP). The collected data were analyzed using SPSS software. According to the results, S. bachtiarica essential oil at doses of 25, 50 and 100 mg/kg and indomethacin caused significant analgesic effects compared to the control group (P<0. 001), and higher analgesic effect was recorded for the dose of 100mg/kg showed. In xylene test, inflammation in groups receiving S. bachtiarica essential oil at doses of 25, 50 and 100 mg/kg and dexamethasone was significantly lower than that of control group (P<0. 001). Our results clearly showed the positive effects of Satureja bachtiarica essential oil in reducing inflammation and pain.
 
Keyword(s): Anti-inflammatory,nociceptive,essential oil,Satureja bachtiarica Bunge,male mice
 
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