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Paper Information

Journal:   MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)   2017 , Volume 31 , Number 1; Page(s) 0 To 0.
 
Paper: 

Immunophenotype evaluation of Non-Hodgkin’ s lymphomas

 
 
Author(s):  SHEIKHPOUR ROBAB*, POURHOSSEINI FATEMEH, NEAMATZADEH HOSSEIN, KARIMI ROGHAYEH
 
* Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
 
Abstract: 
Background: Non-Hodgkin’ s lymphoma (NHLs) is known as a heterogeneous group of malignant lymphoproliferative disorders. NHLs are classified into B cell and T cell types. Immunophenotypical assessment of the biopsy specimens can help diagnose NHLs. Methods: In this study, 77 patients with B cell and T cell lymphoma were selected from Shahid Sadoghi hospital during 2010 to 2013. Immunohistochemical method was used to detect biomarkers like CD2, CD3, CD20, and CD45. Results: In this study, 67 patients (87. 01 %) had B cell lymphoma. Moreover, the most primary tissues in B cell group were lymph node and stomach, followed by bone marrow and neck. Positive co-expression of CD45 and CD20 was found in 61 patients (91. 04%) with B cell lymphoma. However, 10 patients (12. 98%) had T cell lymphoma, and the most primary tissue in T cell lymphoma group was the skin. Moreover, CD3 expression was seen in all patients with T cell lymphoma. Conclusion: This study confirmed the main role of immunohistochemistry method in classifying and diagnosing NHLs. Moreover, the difference in CD marker expression and age in patients with B cell and T cell lymphoma, compared to other studies may be due to geographic area and genetic and ethnic differences.
 
Keyword(s): Non-Hodgkin’s Lymphomas,CD20,CD3,CD2
 
 
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APA: Copy

SHEIKHPOUR, R., & POURHOSSEINI, F., & NEAMATZADEH, H., & KARIMI, R. (2017). Immunophenotype evaluation of Non-Hodgkin’ s lymphomas. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 31(1), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=664933



Vancouver: Copy

SHEIKHPOUR ROBAB, POURHOSSEINI FATEMEH, NEAMATZADEH HOSSEIN, KARIMI ROGHAYEH. Immunophenotype evaluation of Non-Hodgkin’ s lymphomas. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI). 2017 [cited 2021May11];31(1):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=664933



IEEE: Copy

SHEIKHPOUR, R., POURHOSSEINI, F., NEAMATZADEH, H., KARIMI, R., 2017. Immunophenotype evaluation of Non-Hodgkin’ s lymphomas. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), [online] 31(1), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=664933.



 
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