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Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   june 2017 , Volume 15 , Number 6; Page(s) 375 To 382.
 
Paper: 

Polycystic ovary syndrome and circulating inflammatory markers

 
 
Author(s):  ZAFARI ZANGENEH FARIDEH*, NAGHIZADEH MOHAMMAD MEHDI, MASOUMI MASOUMEH
 
* VALI-E-ASR REPRODUCTIVE HEALTH RESEARCH CENTER, IMAM KHOMEINI HOSPITAL, KESHAVARZ BLVD., TEHRAN, 1419733141, IRAN
 
Abstract: 
Background: Human and experimental studies suggest that the sympathetic regulatory drive in the ovary may be unbalanced (hyperactivity) in polycystic ovary syndrome (PCOS). Dysfunctional secretion of interleukin (IL)-1 (α & β ) or related cytokines may thus be related to abnormal ovulation and luteinization. Objective: The aim of this study was the evaluation of cytokines’ pattern in PCOS women and discussion about the explanation of cross-talk between two super systems: sympathetic and immune systems and explanation sympatho-excitation and relationship with interleukins. Materials and Methods: In this study, 171 PCOS women aged between 20-40 years were studied. Their body mass index was <28. The patients were divided into two groups: study group (n=85, PCOS women) and control group (n=86 normal women). The blood sample was obtained on the 3rd day of menstruation cycle. IL-17, IL-1α , IL-1β , and Tumor necrosis factor-alpha (TNF-α ) concentrations were determined in both groups. Results: The median serum level of IL-1α in the PCOS group was higher than the control group (293. 3 and 8. 0, respectively, p<0. 001). Also, the median serum level of IL-1β was higher than the control group (5. 9 and 3. 1 respectively). But the median serum of level IL-17 in women with PCOS was significantly lower than the control group (p<0. 001). Conclusion: Our results confirm that PCOS is a low-level chronic inflammation.
 
Keyword(s): Polycystic ovary syndrome,IL1α-1β,IL-17A,Sympathetic nervous system
 
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