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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   December 2018 , Volume 21 , Number 12; Page(s) 572 To 577.

Comparison of Lipid Ratios to Identify Metabolic Syndrome

Author(s):  Rezapour Maysam, SHAHESMAEILI ARMITA, Hossinzadeh Ali, ZAHEDI RAZIEH, NAJAFIPOUR HAMID, Gozashti Mohammad Hossein*
* Endocrinology and Metabolism Research Center at Kerman University of Medical Sciences, Ibn e Sina Ave., Jahad Blvd., Somayeh Crossroads, Kerman, Iran. Postal code: 7619813159
Background: The objective of this study was to compare various lipid ratios for detection of metabolic syndrome (MetS) in the Iranian general population. Methods: This cross-sectional study involved 5677 subjects aged ≥ 18 years from the general population in Kerman, Iran. Associations between lipid ratio quartiles and MetS were analyzed using logistic regression models. The areas under receiver operating characteristic (ROC) was calculated to determine the accuracy of lipid ratios in predicting MetS. Results: The adjusted chance of having MetS across quartiles of all lipid ratios had an increasing significant pattern (P < 0. 0001). The area under the curves of triglyceride/high-density-lipoprotein-cholesterol (TG/HDL-C) ratio was 0. 85 (95% CI = 0. 84– 0. 87) in men and 0. 85 (95% CI = 0. 84– 0. 86) in women, of total cholesterol (TC)/HDL-C ratio was 0. 79 (95% CI = 0. 77– 0. 81) in men and 0. 79 (95% CI = 0. 77– 0. 81) in women and of low-density-lipoprotein cholesterol (LDL-C)/HDL-C ratio was 0. 73 (95% CI = 0. 71– 0. 75) in men and 0. 74 (95% CI = 0. 72– 0. 76) in women. Conclusion: Our results indicate that the TG/HDL-C Ratio is a better marker than the LDL-C/HDL-C ratio and the TC/HDL-C ratio for identifying MetS in the Iranian population and could be used in clinical practice.
Keyword(s): Area under the curve,Lipid ratios,Metabolic syndrome
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