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Paper Information

Journal:   INTERNATIONAL JOURNAL OF PEDIATRICS   March 2017 , Volume 5 , Number 3 (39); Page(s) 4575 To 4599.
 
Paper: 

Clinical Pharmacokinetics of Gentamicin in Neonates

 
 
Author(s):  PACIFICI GIAN MARIA*, Marchini Giovanna
 
* VIA SAN ANDREA 32, 56127 PISA, ITALY
 
Abstract: 
Gentamicin is a bactericidal aminoglycoside antibiotic, it inhibits the protein synthesis. Gentamicin is active against the majority of aerobic gram-negative bacilli such as Pseudomonas, Klebsiella and Escherichia coli. The gentamicin doses are 3 mg/kg once-daily for preterm newborns < 35 weeks of gestation and 4 mg/kg once-daily for newborns > 35 weeks of gestation. The monitoring of gentamicin serum concentration is recommended when infants are treated for 48 hours or more. The gentamicin peak concentration must be at least 8 times the minimum inhibitory concentration (MIC) to be bactericidal and the gentamicin trough concentration must be < 2 μ g/ml to avoid ototoxicity and nephrotoxicity. Once-daily dosing of gentamicin (4 mg/kg), is preferred than twice-daily dose of 2. 5 mg/kg gentamicin. A gentamicin loading dose (4 mg/kg), followed by once-daily dosing of 2. 5 mg/kg yields safe and target range in neonates. An extended dosing interval of 48-hour (5 mg/kg gentamicin), was compared with twice-daily dose of 2. 5 mg/kg gentamicin. Infants in the 48-hour interval and in the twice-daily achieved peak gentamicin concentrations of 9. 43 μ g/ml and 6. 0 μ g/ml, respectively, (p<0. 001), and trough gentamicin concentrations were 1. 08 μ g/ml and 1. 54 μ g/ml, respectively, (p<0. 001). The infants born small for gestational age have a reduced gentamicin clearance, and a more prolonged gentamicin half-life than infants born appropriate for gestational age. Patent ductus arteriosus, extracorporeal membrane oxygenation, therapeutic hypothermia, and asphyxia reduce the gentamicin clearance.
 
Keyword(s): Effects,Gentamicin,Neonates,Pharmacokinetics,Resistance,Toxicity
 
 
References: 
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Click to Cite.
APA: Copy

PACIFICI, G., & Marchini, G. (2017). Clinical Pharmacokinetics of Gentamicin in Neonates. INTERNATIONAL JOURNAL OF PEDIATRICS, 5(3 (39)), 4575-4599. https://www.sid.ir/en/journal/ViewPaper.aspx?id=663061



Vancouver: Copy

PACIFICI GIAN MARIA, Marchini Giovanna. Clinical Pharmacokinetics of Gentamicin in Neonates. INTERNATIONAL JOURNAL OF PEDIATRICS. 2017 [cited 2021May11];5(3 (39)):4575-4599. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=663061



IEEE: Copy

PACIFICI, G., Marchini, G., 2017. Clinical Pharmacokinetics of Gentamicin in Neonates. INTERNATIONAL JOURNAL OF PEDIATRICS, [online] 5(3 (39)), pp.4575-4599. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=663061.



 
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