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Paper Information

Journal:   INTERNATIONAL JOURNAL OF PEDIATRICS   March 2017 , Volume 5 , Number 3 (39); Page(s) 4569 To 4574.
 
Paper: 

Study of Polymorphism of the DRD2 Gene (-141C Ins/Del, rs1799732) with Attention Deficit Hyperactivity Disorder a Population Sample of Children in Iranian-Azeri

 
 
Author(s):  MEHDIZADEH FANID LEILA*, ADAMPOUREZARE MINA, HOSSEINPOUR FEIZI MOHAMMAD ALI, Noorazar Gholamreza
 
* Department of Biology, Faculty of Natural Sciences, University of Tabriz, 29 Bahman Bolvard, Tabriz, Iran, IR
 
Abstract: 
Background Attention deficit hyperactivity disorder (ADHD), is a multifactorial disorder and converging evidence has implicated abnormalities of dopamine neurotransmission. The aim of this study was to examine the association of-141 polymorphisms in DRD2 gene with ADHA among Iranian-Azeri population. Materials and Methods A case– control association study included 153 patients with attention deficit hyper activity disorder (case group), and 133 healthy subjects (control group). Genomic DNA was extracted peripheral blood samples by salting-out method. Single nucleotide polymorphism (SNP) genotyping was performed by Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The data analysis was performed through Chi-square, with a significance level of 0. 05. Results: There was not significant difference in the allele and genotype frequencies between ADHD and-141C Ins/Del polymorphism in cases and controls (P>0. 05). Ins/Ins homozygous dominants were more frequent in control group than the case group, but there was not significant difference observed (P>0. 05). Del/Del homozygous dominants were not observed. No significant difference was detected in the allele and genotype frequencies between ADHD and-141 Insertion/Deletion polymorphism in cases and control groups (P>0. 05). Conclusion Our results do not detected association between the-141C Ins/Del, rs1799732, polymorphism and ADHD disorder in population of Children in Iranian-Azeri.
 
Keyword(s): ADHD,DRD2 gene,Iranian children,Polymorphism
 
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