Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   November 2016 , Volume 19 , Number 11; Page(s) 762 To 766.
 
Paper: 

Clinical Spectrum of Celiac Disease in Children in Sistan and Baluchestan Province

 
DOI: 

0161911/AIM.004

 
Author(s):  SHAHRAKI TOURAN*, Hill Ivor D.
 
* Department of Pediatrics, Faculty of Medicine, Zahedan University of Medical Sciences, Research Center for Children and Adolescent Health, Zahedan, I. R. of Iran
 
Abstract: 
Background: The clinical manifestations of celiac disease (CD) have changed in the past decades. There are currently little data describing the initial clinical manifestations of CD in children in Iran. This study describes the initial presentation of children with suspected 􀀦 􀀧 􀀃 􀁉 􀁕 􀁒 􀁐 􀀃 􀁄 􀀃 􀁊 􀁈 􀁒 􀁊 􀁕 􀁄 􀁓 􀁋 􀁌 􀁆 􀁄 􀁏 􀁏 􀁜 􀀃 􀁇 􀁈 􀂿 􀁑 􀁈 􀁇 􀀃 􀁕 􀁈 􀁊 􀁌 􀁒 􀁑 􀀃 􀁌 􀁑 􀀃 􀀬 􀁕 􀁄 􀁑 􀀑 Method: Medical records of children seen in 2007 – 2015 from Sistan and Baluchestan province, Iran, with suspected CD were reviewed. After obtaining TTG-IgA and IgA, subjects were divided into three groups according to presenting symptoms: GI, non-GI, and asymptomatic group. Those with elevated TTG-IgA or a strong clinical suspicion for CD underwent endoscopy with duodenal biopsy. Demographic data, 􀁖 􀁜 􀁐 􀁓 􀁗 􀁒 􀁐 􀁖 􀀏 􀀃 􀁏 􀁄 􀁅 􀁒 􀁕 􀁄 􀁗 􀁒 􀁕 􀁜 􀀏 􀀃 􀁋 􀁌 􀁖 􀁗 􀁒 􀁓 􀁄 􀁗 􀁋 􀁒 􀁏 􀁒 􀁊 􀁜 􀀃 􀂿 􀁑 􀁇 􀁌 􀁑 􀁊 􀁖 􀀃 􀁄 􀁑 􀁇 􀀃 􀁗 􀁋 􀁈 􀀃 􀁓 􀁕 􀁈 􀁖 􀁈 􀁑 􀁆 􀁈 􀀃 􀁒 􀁉 􀀃 􀁄 􀁑 􀁜 􀀃 􀀦 􀀧 􀀃 􀁕 􀁈 􀁏 􀁄 􀁗 􀁈 􀁇 􀀃 􀁆 􀁒 􀁑 􀁇 􀁌 􀁗 􀁌 􀁒 􀁑 􀁖 􀀃 􀁚 􀁈 􀁕 􀁈 􀀃 􀁕 􀁈 􀁆 􀁒 􀁕 􀁇 􀁈 􀁇 􀀑 􀀃 Results: from 344 children who underwent upper endoscopy and intestinal biopsy, 105 cases with marsh 0 – 1 were excluded from the 􀁖 􀁗 􀁘 􀁇 􀁜 􀀃 􀁄 􀁑 􀁇 􀀃 􀀕 􀀖 􀀜 􀀃 􀁆 􀁄 􀁖 􀁈 􀁖 􀀃 􀁆 􀁒 􀁑 􀁖 􀁌 􀁇 􀁈 􀁕 􀁈 􀁇 􀀃 􀁄 􀁖 􀀃 􀁄 􀀃 􀁇 􀁈 􀂿 􀁑 􀁌 􀁗 􀁈 􀀃 􀁆 􀁈 􀁏 􀁌 􀁄 􀁆 􀀃 􀁇 􀁌 􀁖 􀁈 􀁄 􀁖 􀁈 􀀃 􀀋 􀀰 􀁈 􀁄 􀁑 􀂓 􀀃 􀀶 􀀧 􀀃 􀁒 􀁉 􀀃 􀁄 􀁊 􀁈 􀀃 􀁚 􀁄 􀁖 􀀃 􀀙 􀀑 􀀛 􀀃 􀂓 􀀃 􀀖 􀀑 􀀜 􀀃 􀁜 􀁈 􀁄 􀁕 􀁖 􀀃 􀁚 􀁌 􀁗 􀁋 􀀃 􀀔 􀀗 􀀘 􀀃 􀁉 􀁈 􀁐 􀁄 􀁏 􀁈 􀁖 􀀌 􀀑 􀀃 􀀪 􀀬 􀀃 􀁖 􀁜 􀁐 􀁓 􀁗 􀁒 􀁐 􀁖 􀀃 􀁚 􀁈 􀁕 􀁈 􀀃 predominant in the younger age groups while non-GI symptoms were more common in the older children. The most frequent GI and Non-GI symptoms were abdominal pain (41. 4%), distension (36. 4%), diarrhea (32. 2%), under nutrition (51. 4%), anemia (36. 4%), and decreased bone age (35%). The most common co-morbidities were hypothyroidism (3. 7%) and Type 1 diabetes (2. 9%). Conclusion: GI complaints in Iranian children are a common feature. Screening of children with suspected CD, especially with GI symptom is highly recommended.
 
Keyword(s): Celiac disease,children,disease,Iran
 
References: 
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