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Paper Information

Journal:   JOURNAL OF VETERINARY RESEARCH   2017 , Volume 72 , Number 3 #f00614; Page(s) 355 To 363.

The effect of turmeric extract and sodium bentonite on some biochemical parameters in rats contaminated with Aflatoxin B1

Author(s):  Rialy a., Sarir h.*, Mojtahedi m., Abtahi h.
* Department of Animal Science, University of Birjand, Birjand, Iran
BACKGROUND: Aflatoxins are a group of mycotoxins produced by Aspergillus flavus and Aspergillus parasiticus and are an important factor in oxidative damage to the kidney and liver. OBJECTIVES: The purpose of this study was to evaluate the effects of turmeric extract and/or sodium bentonite against renal and hepatic damage induced by aflatoxin B1. METHODS: In this experiment, which lasted for four weeks, 64 male Wistar rats were randomly assigned to eight groups including: control, aflatoxin (AF), turmeric extract (TE), sodium bentonit (SB), TE+SE, AF+TE, AF+SB, AF+(TE+SB). At the end of experiment blood samples were taken from heart and some biochemical analyses were performed. RESULTS: In the AF group, the levels of alanine aminotransferase (ALT), alkaline phosphatase (ALP), low density lipoprotein (LDL) and creatinine (p<0. 05) significantly increased and uric acid numerically increased (p=0. 056) compared to control group. Treatment of AF contaminated group with TE or SB alone remarkably decreased the levels of ALT, ALP, creatinine and uric acid. TE and SB in normal rats had no significant effect on the levels of liver enzyme compared to the control group. CONCLUSIONS: According to the present research, it seems that TE and SB alone decrease the harmful effects of Aflatoxin B1 and the combination of them has a potentiating effect.
Keyword(s): aflatoxin B1,turmeric extract,sodium bentonite,blood factors,rats
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