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Paper Information

Journal:   OFOGH-E-DANESH   SUMMER 2016 , Volume 22 , Number 3 ; Page(s) 185 To 191.
 
Paper: 

PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OFSALVIA OFFICINALIS L. AGAINST ACUTE LIVER TOXICITY OF ACETAMINOPHEN IN MICE

 
 
Author(s):  FORUOZANDEH H.*, VOSUGHI NIRI M., KALANTAR M., AZADI M., SAMADANI M.
 
* STUDENT RESEARCH COMMITTEE, AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IRAN, POSTAL CODE: 74371-58385
 
Abstract: 

Aims: The medical herbs play important roles in the treatment of liver diseases.
In the traditional medicine, Salvia officinal is is highly used to heal a wide range of diseases. The aim of this study was to investigate the treatment effects of Saliva officinali son hepatotoxicity due to acetaminophen.
Materials & Methods: In the experimental study, 60 albino mice were studied.
The rats were divided into 6 groups. The first, second, and third groups were physiological serum, crude extract of Saliva officinal is, and 500mg acetaminophen per 1Kg consumed as single dose, respectively. The fourth, fifth, and sixth groups received 5-day 125, 250, and 500mg per 1Kg extract of Saliva officinal is, respectively. Then, they received 500mg acetaminophen one hour after the last administration of extract. Blood sampling was done from the carotids of the rats 24hour later, and the levels of bilirubin and liver enzymes were measured. In addition, their liver tissues were studied. Data was analyzed by SPSS 16 software using one-way ANOVA.
Findings: There were significant increases in the direct and complete bilirubin concentration and liver enzymes due to acetaminophen compared to control group (p<0.05). There were significant reductions in the direct and complete bilirubin and liver enzymes due to 125, 250, and 500mg per 1Kg of the extract of Saliva officinal is compared to control group (p<0.05). The results were confirmed by the histology studies.
Conclusion: 250 and 500mg per 1Kg of Saliva officinal is potentially protect the damages caused by acetaminophen. In addition, they considerably improve the tissue damage and the biochemical indices in the liver damages.

 
Keyword(s): ACETAMINOPHEN, SALVIA OFFICINAL IS, HEPATOTOXICITY
 
References: 
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